Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats

Figure 1

Representative histopathology slides (×20) of rat livers from control (untreated) and NVP treated rats and their respective pathology reports. (a) (No NVP): untreated group. “No pathology appears to be present in the control (untreated) animals”; (b) (NVP × 2 days): treated with NVP for 2 days. “Mild granular vacuolar degeneration and cell swelling, scattered cytonecrosis, nuclear pyknosis. Zonal necrosis... minimally present.”. (c) (NVP × 7 days): treated with NVP for 7 days. “vacuolar degeneration and cell swelling were moderate, single cell necrosis (cytonecrosis)... minimal centrilobular necrosis.”. (d) (NVP × 14 days): treated with NVP for 14 days. “moderate cellular swelling, vacuolar hepatopathy (degeneration) and granular cytoplasm... Hepatic parenchymal cell necrosis (cytonecrosis), and centrilobular zonal necrosis”. (e) (NVP × 28 days): treated with NVP for 28 days. “Granular vacuolar degeneration and cell swelling were minimal, as well as cytonecrosis.”. (f) (NVP × 42 days): treated with NVP for 42 days. “Centrilobular hepatocytes with minimal (1+) degeneration visible”.

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