Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats

Figure 2

Representative histopathology slides (×20) of rat livers from control (untreated) and isoniazid (INH) treated rats and their respective pathology reports. (a) (No INH): untreated group. “No pathology appears to be present in the control (untreated) animals”; (b) (INH × 2 days): treated with INH for 2 days. “Moderate granular vacuolar degeneration, loss of coordinated and well-organized hepatocytic cords. The cytoplasm appeared to be cloudy and granular, centrilobular zonal necrosis was minimal”. (c) (INH × 7 days): treated with INH for 7 days. “Severe degeneration of vacuoles and osmotic swelling of the mitochondria, cytonecrosis was moderate, loss of cell boundaries and nuclei”. (d) (INH × 14 days): treated with INH for 14 days. “Degenerative changes, cytonecrosis was present, disruption of the cytoplasm, minimal zonal necrosis was observed”. (e) (INH × 28 days): treated with INH for 28 days. “moderate cell swelling, mild cytonecrosis, hepatocytes appear swollen with granular cytoplasm.”. (f) (INH × 42 days): treated with INH for 42 days. “The histopathological lesions had improved, minimal cytonecrosis, centrilobular zonal necrosis was completely absent... one mitotic figure”.

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