Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study

Table 1

Level of TBARS, GSH, SOD, and catalase in myocardial tissue.

S. number	Treatment	TBARS (nmol/gm wet wt)	GSH (µg/gm wet wt)	SOD (IU/dL)	Catalase (IU/dL)
1	Group I	57.3 ± 10.3	222.1 ± 5.3	18.7 ± 6.3	21.73 ± 0.59
2	Group II	117.1 ± 36.8^##	55.7 ± 5.9^##	6.46 ± 0.13^#	5.4 ± 0.55^##
3	Group III	58.6 ± 1.1	61.04 ± 3.3	9.7 ± 4.9	6.04 ± 0.24
4	Group IV	52.2 ± 2.8	80.4 ± 10.2	13.4 ± 9.5	7.7 ± 1.03
5	Group V	43.6 ± 2.7	200.2 ± 8.1	26.4 ± 8.6	19.8 ± 0.78

All values were expressed as mean ± SEM, One-Way Analysis of Variance, followed by Dunnett’s and versus Group I and , and   versus Group II.
Group I: rats treated with saline (10 mL/kg p.o).
Group II: rats treated with saline (10 mL/kg p.o) and subjected to in vitro global ischemia
Group III: rats treated with Ramipril (2 mg/kg p.o) and subjected to in vitro global ischemia.
Group IV: rats treated with Candesartan (1 mg/kg p.o) and subjected to in vitro global ischemia.
Group V: rats treated with combination of both drugs and subjected to in vitro global ischemia.