Histopathological changes of the myocardium and aorta. (a) The NC group rat heart revealed the noninfarcted architecture of the myocardium. (b) The HF-DC group rats showed myofibril damage and demonstrated marked edema, confluent areas of myonecrosis separation of myofibers, congested blood vessels, and mild inflammation. (c) NC group rat aorta showed the normal architecture. (d) Histopathology of HF-DC aorta showed fat cell deposition in vessel wall (atherosclerosis).