(a)
(b)
Figure 1: (a) Several different factors may contribute to the development and progression of POAG, finally triggering cell death, usually by apoptosis, of RGC. These factors could be considered potential targets of neuroprotective agents. (b) Due to the multifactorial nature of POAG, pleiotropic effects are expected from neuroprotective agents in order to achieve efficient neuroprotection.