Antidiabetic Effects of the Ethanolic Root Extract of Uvaria chamae P. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus
Table 1
Effect of the root extract of U. chamae on blood glucose (mg/dl) in alloxan-induced diabetes mellitus and percentage reduction in blood glucose (%).
Days
Control (2% acacia)
Glibenclamide (71 µg/kg)
Pioglitazone (429 µg/kg)
UC (100 mg/kg)
UC (250 mg/kg)
UC (400 mg/kg)
Diabetic untreated
0
86.75 ± 2.36
76.00 ± 3.22
83.33 ± 9.20
88.33 ± 3.76
71.33 ± 3.76
77.67 ± 4.26
65.33 ± 5.90
1
91.75 ± 1.93
357.7 ± 28.30
352.3 ± 9.40
359.0 ± 16.10
337.3 ± 6.70
501.7 ± 56.30
264.0 ± 5.80
3
82.00 ± 3.20
222.3 ± 51.40 (37.85)
239.0 ± 38.40 (32.16)
284.7 ± 22.40 (20.70)
270.7 ± 18.8 (19.75)
280.3 ± 8.30 (44.13)
272.0 ± 2.00 (−3.03)
5
84.00 ± 3.00
189.0 ± 48.80 (47.16)
173.7 ± 35.80 (50.70)
198.7 ± 64.30 (44.65)
94.0 ± 7.50 (72.13)
157.0 ± 61.10 (68.71)
282.3 ± 1.50 (−6.93)
7
78.25 ± 4.27
132.0 ± 16.80 (63.10)
245.0 ± 59.81 (30.46)
100.0 ± 11.68 (72.14)
71.67 ± 9.17 (78.75)
61.67 ± 1.86 (87.71)
288.7 ± 0.88 (−9.36)
9
90.25 ± 3.10
117.0 ± 11.90 (67.29)
275.3 ± 48.40 (21.86)
91.67 ± 13.60 (74.47)
70.33 ± 8.70 (79.15)
58.33 ± 6.40 (88.37)
297.7 ± 1.20 (−12.77)
11
84.75 ± 2.50
109.3 ± 10.30 (69.44)
202.3 ± 70.50 (42.58)
90.33 ± 9.20 (74.84)
73.0 ± 4.00 (78.36)
50.33 ± 7.40 (89.97)
305.3 ± 4.80 (−15.64)
13
83.50 ± 4.90
100.0 ± 7.50 (72.04)
145.7 ± 77.70 (58.64)
79.0 ± 10.70 (77.99)
68.33 ± 2.00 (79.74)
55.0 ± 7.60 (89.04)
312.7 ± 9.20 (−18.45)
15
79.75 ± 3.50
93.0 ± 5.60 (74.00)
158.3 ± 59.30 (55.07)
75.0 ± 10.00 (79.11)
72.33 ± 4.30 (78.56)
59.67 ± 6.40 (88.11)
318.7 ± 11.30 (−20.72)
Significant difference (;) between the mean ± SEM of test groups vs. control. UC: Uvaria chamae.
