Research Article
Studies on the Dual Cytotoxicity and Antioxidant Properties of Berberis vulgaris Extracts and Its Main Constituent Berberine
Table 3
Combination index determination for the combined effect of berberine and NO donor (SNAP).
| | Berberine (μM) | SNAP (IC30 μM) | Fa (B + S) | CI | Descriptiona |
| | 0.525 | 15.84 | 0 | 14.7 | Antagonism | | 1.050 | 15.84 | 0.755 | 13.8 | Antagonism | | 2.10 | 15.84 | 6.410 | 8.8 | Antagonism | | 4.20 | 15.84 | 22.381 | 2.6 | Antagonism | | 8.40 | 15.84 | 39.555 | 0.7 | Synergy | | 16.80 | 15.84 | 49.361 | 0.5 | Synergy | | 33.60 | 15.84 | 52.010 | 0.6 | Synergy | | 67.20 | 15.84 | 52.285 | 1.2 | Antagonism | | 134.40 | 15.84 | 53.103 | 2.1 | Antagonism | | 268.80 | 15.84 | 73.204 | 1.4 | Antagonism | | 537.60 | 15.84 | 80.507 | 1.1 | Antagonism | | 1075.20 | 15.84 | 81.749 | 1.9 | Antagonism |
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Fa: affected fraction; B: berberine; S: SNAP; B + S: berberine + SNAP; CI: combination index. aCI = 1.00: additive effect; CI < 1.00: synergistic effect; CI > 1.00: antagonistic effect.
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