Efficacy of Aloe vera, Ananas comosus, and Sansevieria masoniana Cream on the Skin Wound Infected with MRSA
Table 3
Effects of the herbal cream formulation on the skin wound infected with MRSA.
Parameter
Group
Day
5
10
15
Percentage of wound closure (%)
1 (C)
3.60 ± 1.05
29.94 ± 2.72
54.36 ± 5.75
2 (BC)
4.51 ± 1.37
32.04 ± 3.88
59.63 ± 2.69
3 (AV)
10.00 ± 0.76
64.17 ± 4.86
99.10 ± 1.18
4 (AC)
12.82 ± 4.07
63.67 ± 5.80
99.06 ± 1.62
5 (SM)
9.25 ± 0.78
42.04 ± 9.13
87.02 ± 9.49
Skin tensile strength (grams)
1 (C)
NT
NT
218.33 ± 9.50
2 (BC)
NT
NT
219.33 ± 5.85
3 (AV)
NT
NT
578.00 ± 12.00
4 (AC)
NT
NT
566.67 ± 28.29
5 (SM)
NT
NT
500.67 ± 15.56
Angiogenesis
1 (C)
0.50 ± 0.54
0.83 ± 0.40
1.00 ± 0.63
2 (BC)
0.50 ± 0.54
1.33 ± 0.51
1.66 ± 0.51
3 (AV)
1.50 ± 0.54
2.16 ± 0.40
2.66 ± 0.51
4 (AC)
1.33 ± 0.51
1.83 ± 0.75
2.66 ± 0.81
5 (SM)
1.16 ± 0.75
1.83 ± 0.75
2.50 ± 0.83
Inflammatory cells infiltration
1 (C)
3.00 ± 0.00
2.00 ± 0.89
2.00 ± 0.63
2 (BC)
3.00 ± 0.00
2.66 ± 0.51
2.16 ± 0.75
3 (AV)
2.50 ± 0.54
1.83 ± 0.75
0.83 ± 0.75
4 (AC)
2.33 ± 0.51
2.00 ± 0.63
1.00 ± 0.63
5 (SM)
2.50 ± 0.83
1.50 ± 0.83
1.33 ± 0.51
Fibroblast
1 (C)
0.66 ± 0.51
1.16 ± 0.75
1.50 ± 0.54
2 (BC)
0.66 ± 0.81
1.50 ± 0.54
1.50 ± 0.54
3 (AV)
1.66 ± 0.51
2.00 ± 0.63
2.50 ± 0.83
4 (AC)
1.33 ± 0.81
1.83 ± 0.40
2.66 ± 0.51
5 (SM)
1.33 ± 0.81
2.00 ± 0.63
2.66 ± 0.51
Collagen deposition
1 (C)
0.16 ± 0.40
0.83 ± 0.40
1.33 ± 0.81
2 (BC)
0.33 ± 0.51
1.00 ± 0.63
1.33 ± 0.81
3 (AV)
1.16 ± 0.40
1.66 ± 0.51
3.00 ± 0.00
4 (AC)
0.66 ± 0.51
1.66 ± 0.51
2.50 ± 0.54
5 (SM)
1.00 ± 0.63
1.66 ± 0.51
1.66 ± 0.51
Expression of CD8+ lymphocytes
1 (C)
0.16 ± 0.40
0.83 ± 0.75
1.33 ± 0.81
2 (BC)
0.33 ± 0.51
0.66 ± 0.51
1.50 ± 0.54
3 (AV)
2.83 ± 0.40
2.33 ± 0.51
0.66 ± 0.51
4 (AC)
2.33 ± 0.81
2.16 ± 0.75
1.00 ± 0.63
5 (SM)
2.00 ± 1.26
2.00 ± 0.63
1.50 ± 0.54
NT, not tested; the values are expressed as mean ± SD; the different superscript on the same column and parameter showed significantly different values ().
