Evaluation of Novel 3-Hydroxyflavone Analogues as HDAC Inhibitors against Colorectal Cancer

Figure 1

Synthesis of 3-hydroxyflavone analogues was carried out by the reaction of various substituted acetophenones with substituted benzaldehyde using 40% KOH and methanol to form chalcones (1a–f). The chalcones were cyclized using 10% KOH, methanol, and 15% H₂O₂ to produce 3-hydroxyflavones (QMJ-1–6).