Research Article
Toxicity and Safety Evaluation of Doxorubicin-Loaded Cockleshell-Derived Calcium Carbonate Nanoparticle in Dogs
Figure 10
Photomicrograph of the myocardium. (a) Myocardium of the dogs given normal saline showing the normal morphological architecture of myocardial fibres. (b) Free DOX 150 mg/m2 showing collagen deposit within the interstitial myocardial space of myocardial fibres. (c) CS-CaCO3NP-DOX 150 mg/m2 showing basophilic cardiomyocytes with the myocardial fibres (Masson’s trichrome). Scale bar 10 µm.
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