Research Article

Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One

Table 2

Results of the sedative activity of 4-phenyl-1,5-benzodiazepin-2-one at doses of 100 and 200 mg/kg ( compared to controls).

WitnessReference (bromazepam 20 mg/kg)4-Phenyl-1,5-benzodiazepin-2-one (100 mg/kg)4-Phenyl-1,5-benzodiazepin-2-one (200 mg/kg)

Traction testPercentage of falls (%)010000
Average fall time (s)010.0 ± 0.900
Average recovery time (s)0.50 ± 0.1001.68 ± 0.106.12 ± 5.44
Chimney testAverage time to climb the chimney (s)3.40 ± 0.50>1201.80 ± 1.648.16 ± 5.64
Hole-board testNumber of holes explored over 5 min7 ± 10 ± 03.48 ± 2.223.36 ± 2.55
Rota-Rod testTime spent on the stem (s)120 ± 01.2 ± 0.90120 ± 0120 ± 0