Research Article
Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One
Table 2
Results of the sedative activity of 4-phenyl-1,5-benzodiazepin-2-one at doses of 100 and 200 mg/kg (
compared to controls).
| | | Witness | Reference (bromazepam 20 mg/kg) | 4-Phenyl-1,5-benzodiazepin-2-one (100 mg/kg) | 4-Phenyl-1,5-benzodiazepin-2-one (200 mg/kg) |
| Traction test | Percentage of falls (%) | 0 | 100 | 0 | 0 | Average fall time (s) | 0 | 10.0 ± 0.9 | 0 | 0 | Average recovery time (s) | 0.50 ± 0.10 | 0 | 1.68 ± 0.10 | 6.12 ± 5.44 | Chimney test | Average time to climb the chimney (s) | 3.40 ± 0.50 | >120 | 1.80 ± 1.64 | 8.16 ± 5.64 | Hole-board test | Number of holes explored over 5 min | 7 ± 1 | 0 ± 0 | 3.48 ± 2.22 | 3.36 ± 2.55 | Rota-Rod test | Time spent on the stem (s) | 120 ± 0 | 1.2 ± 0.90 | 120 ± 0 | 120 ± 0 |
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