Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One

Table 5

Results of the drug interaction of thiopental sodium with 5i ( compared to controls).

Time	Witness thiopental sodium (40 mg/kg)	Reference thiopental sodium (40 mg/kg) + bromazepam (30 mg/kg)	Thiopental sodium (40 mg/kg) + 5a (100 mg/kg)	Thiopental sodium (40 mg/kg) + 5b (100 mg/kg)	Thiopental sodium (40 mg/kg) + 5c (100 mg/kg)	Thiopental sodium (40 mg/kg) + 5d (100 mg/kg)
TE (s)	180 ± 60	105 ± 57	167 ± 50.49	99 ± 22.09	81 ± 29.98	117 ± 25
TS (min)	45 ± 20	231 ± 13.25	153 ± 59.61	118 ± 46.18	88 ± 25.31	82 ± 12.76