Advances in Pharmacological and Pharmaceutical Sciences / 2018 / Article / Tab 3

Review Article

Therapeutic Properties of Stingless Bee Honey in Comparison with European Bee Honey

Table 3

Summary of therapeutic properties of European bee honey and stingless bee honey from previous studies.

PropertiesHoney types and bee speciesTherapeutic effectsReference

AntidiabeticNigerian honey (Apis spp.)Increased high-density lipoprotein (HDL) cholesterol[61]
Reduced hyperglycemia, triglycerides (TGs), very low-density lipoprotein (VLDL) cholesterol, non-HDL cholesterol, coronary risk index (CRI), and cardiovascular risk index
Gelam honey (Apis dorsata)Increased expression of phosphorylated JNK and JKK-β. Reduced expression of TNF‐α, IL‐6, IL‐1β, and Akt phosphorylation[62]
Expression of TNF-α, IL-6, IL-1β, and Akt phosphorylation
European bee honey (Apis spp.)No effect on glucose level at low dosage[63]
Increased blood glucose at high dosage
European bee honey and stingless bee honey (Apis cerana indica, Apis mellifera, Apis dorsata, Apis florae, and Trigona iridipennis)Higher percentage of inhibition against α-amylase and α-glucosidase enzyme (Trigona sp.)[64]
Stingless bee honey (Geniotrigona thoracica)Prevent increased of fasting-blood glucose (FBG), total cholesterols (TC), TGs, and LDL levels[65]
Increased HDL and serum insulin levels
Decreasedchanges of histopathological and oxidative stress expression level, inflammation, and apoptosis markers in pancreatic islets
Increased expression level of insulin

Wound healingMultifloral honey, West Bengal (Apis mellifera)Close resemblance of D-spacing and collagen diameter to normal skin collagen (scanning electron microscope observation)[66]
Multifloral honey, Iran (Apis mellifera)Increased Oedema and necrosis[67]
Less infiltration of polymorphonuclear and mononuclear cells
Improve wound contraction
Increased epithelialisation
Increased concentrations of glycosaminoglycan and proteoglycan
Multifloral honey, Ibadan, Nigeria (Apis mellifera)Increased granulation tissue in electroscalpel (ES) wound[68]
Increased fibroelastic tissue in honey treated wounds of ES group and honey treated wound cold scalpel
Tualang honey (Apis dorsata)High tensile strength of colon anastomosis and fibroblast count[69]
High inflammatory cells
European bee honey (Apis spp.)High hydroxyproline level in jaundiced animals treated with honey[70]
High bursting pressure
Stingless bee honey (Trigona spp.)Prevent growth of rifampicin-resistant S. aureus and maintaining the sensitivity of S. aureus towards rifampicin[71]
Stingless bee honey (Apis mellipodae)Showed effective effects in inhibiting growth of S. aureus and other pathogenic bacteria[11]
European bee honey (Apis spp.)Stimulates healing process, clears infection, stimulates tissue regeneration, and reduces Inflammation[58, 72, 73]

AnticancerEuropean bee honey (Apis mellifera)Increased number of viable HepG2 cells in the human hepatoma cell (HepG2) treatment[74]
Improvement of the total antioxidant status
Caspase-3 activity is time and dose-dependent
Multifloral honey (Apis mellifera)Increased rate of incidence, the efficacy to multiply, and the tumor size[75]
Stingless bee (Trigona spp.)Reduced the total number of ACF and aberrant crypt and multiplicity of crypt[76]
No changes in the level of blood profile parameters, liver enzymes, and kidney functions
Trigona incisa, Timia apicalis, Trigona fusco-balteata, and Trigona fuscibasisIncreased cytotoxicity effects towards HepG2 cell line, while propolis crude extracts exhibit high cytoxicity effects towards all the human cancer cell lines[77]
Treatment of eye diseasesHoneydew honey(Apis mellifera)Bacterial flora in the conjunctival sac of patients with cataract and scheduled for vitrectomy was successfully eradicated after 7 days[78]
Australian and New Zealand honey (Leptospermum sp.)Reduced formation of the whole colony-forming units in the eyelids and conjunctivae in patients with dry eye syndrome after one and three months of therapy[79]
Tualang honey (Apis dorsata)No difference between the conventional treatment with Tualang honey eye treatment for chemical eye injury[80]
European bee honey (Apis spp.)Corneas manifested an immediate regression of the corneal oedema[81]
Stingless bee (Trigona spp.)Retardation of the cataract progress in 20% of the rats in the group that received honey for the opacification treatment[82]
Stingless bee honey (Meliponula spp.)Reduced the infection time for eye diseases caused by Staphylococcus aureus and Pseudomonas aeruginosa[83]

FertilityTualang honey (Apis dorsata)Increased intromission and ejaculation percentage in rats[84]
Increased rate of fertility and mating
Honey Uremia, Iran (Apis spp.)Reduced apoptosis and necrosis rate of the testicular cells in cells affected by noise stress and thereby increased cell viability[85]
Tualang honey (Apis dorsata)Beneficial effects on level of corticosterone, pregnancy outcome, and adrenal histomorphometry[86]
Tualang honey (Apis dorsata)Reduced cortisol and increased progesterone level of stress-induced female rats[87]
Increased testicular, epididymal weights, epididymal sperm count, motility, viability in nondiabetic, and sperm quality[88]

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.