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No | References | Animals | Doses | Main findings |
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1 | Sakurai et al. 2009 [19] | Sprague-Dawley rats | 1,25D (10 ng/kg body wt) or 3-epi-1,25D (50 ng/kg body wt) once daily | Vitamin D works in the lung maturation of perinatal rats |
2 | Zosky et al. 2011 [20] | Newborn BALB/c mice | (2,195 IU/kg) diets (Specialty Feeds, Glen Forrest, Western Australia), (500 ng/g) | Vitamin D deficiency decreased the lung volume |
3 | Yurt et al. 2014 [21] | Sprague-Dawley rats | 250 IU/kg cholecalciferol (no. 1814547), 500 IU/kg cholecalciferol (no. 1814548), 1,000 IU/kg cholecalciferol (no. 1814549) | Vitamin D at 500 IU/kg effectively blocks the deficiency of VD |
4 | Dancer et al. 2015 [22] | Wild-type (WT) C57Bl/6 | — | Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) |
5 | Shi et al. 2016 [23] | Mice with a C57BL/6J | — | Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier |
6 | Xu et al. 2017 [24] | Wistar rats | 1, 5 or 25 mg/kg calcitriol | Vitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system |
7 | Klaff et al. 2012 [25] | C57BL/6 mice | 1000 IU/kg of cholecalciferol | Found no difference in the degree of lung injury |
8 | Mandell et al. 2014 [26] | Sprague-Dawley rats | (500 ng/g) | Vitamin D increased alveolar type II cells (ATII) in fetal rats |
9 | Lykkedegn et al. 2016 [27] | Female Sprague-Dawley rats | <5 IU/kg of cholecalciferol, 1500 IU/kg of cholecalciferol | Vitamin D deficiency induces lower oxygenation and reduces the survival time in preterm rats |
10 | Chen et al. 2015 [28] | Male Wistar rats | Vitamin D at 4, 1, 4, and 10 μg/kg | Vitamin D works to block airway inflammation |
11 | Chen L et al. 2016 [29] | Female BALB/c mice | (0 vitamin D3). (2195 IU/kg vitamin D3) diets (Specialty Feeds, Glen Forrest, Western Australia) | Vitamin D deficiency may influence lung structure and function in early postnatal mice |
12 | Taylor et al. 2016 [30] | Sprague-Dawley rats | 25(OH) D subdivided into 100, 500, or 1000 ng/kg. 1,25D, subdivided into 1, 10, or 50 ng/kg | Vitamin D is relatively safe and effective in the lung maturation of neonatal rats |
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