Review Article

Updates on the Status of Vitamin D as a Risk Factor for Respiratory Distress Syndrome

Table 2

Reports of the correlation between vitamin D deficiency and respiratory distress syndrome in animal studies.

NoReferencesAnimalsDosesMain findings

1Sakurai et al. 2009 [19]Sprague-Dawley rats1,25D (10 ng/kg body wt) or 3-epi-1,25D (50 ng/kg body wt) once dailyVitamin D works in the lung maturation of perinatal rats
2Zosky et al. 2011 [20]Newborn BALB/c mice(2,195 IU/kg) diets (Specialty Feeds, Glen Forrest, Western Australia), (500 ng/g)Vitamin D deficiency decreased the lung volume
3Yurt et al. 2014 [21]Sprague-Dawley rats250 IU/kg cholecalciferol (no. 1814547), 500 IU/kg cholecalciferol (no. 1814548), 1,000 IU/kg cholecalciferol (no. 1814549)Vitamin D at 500 IU/kg effectively blocks the deficiency of VD
4Dancer et al. 2015 [22]Wild-type (WT) C57Bl/6Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
5Shi et al. 2016 [23]Mice with a C57BL/6JVitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier
6Xu et al. 2017 [24]Wistar rats1, 5 or 25 mg/kg calcitriolVitamin D alleviates lipopolysaccharide-induced acute lung injury via regulation of the renin-angiotensin system
7Klaff et al. 2012 [25]C57BL/6 mice1000 IU/kg of cholecalciferolFound no difference in the degree of lung injury
8Mandell et al. 2014 [26]Sprague-Dawley rats(500 ng/g)Vitamin D increased alveolar type II cells (ATII) in fetal rats
9Lykkedegn et al. 2016 [27]Female Sprague-Dawley rats<5 IU/kg of cholecalciferol, 1500 IU/kg of cholecalciferolVitamin D deficiency induces lower oxygenation and reduces the survival time in preterm rats
10Chen et al. 2015 [28]Male Wistar ratsVitamin D at 4, 1, 4, and 10 μg/kgVitamin D works to block airway inflammation
11Chen L et al. 2016 [29]Female BALB/c mice(0 vitamin D3). (2195 IU/kg vitamin D3) diets (Specialty Feeds, Glen Forrest, Western Australia)Vitamin D deficiency may influence lung structure and function in early postnatal mice
12Taylor et al. 2016 [30]Sprague-Dawley rats25(OH) D subdivided into 100, 500, or 1000 ng/kg. 1,25D, subdivided into 1, 10, or 50 ng/kgVitamin D is relatively safe and effective in the lung maturation of neonatal rats