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Advances in Pharmacological Sciences
Volume 2018, Article ID 9794625, 15 pages
https://doi.org/10.1155/2018/9794625
Review Article

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

1Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
2Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad 38000, Pakistan
3Department of Biochemistry, University of Agriculture, Faisalabad 38000, Pakistan
4Department of Medical Biology, Faculty of Medicine, Nigde Ömer Halisdemir University, Nigde 51240, Turkey

Correspondence should be addressed to Azhar Rasul; moc.liamg@lusarrahzard

Received 8 January 2018; Revised 5 April 2018; Accepted 12 April 2018; Published 2 May 2018

Academic Editor: Paola Patrignani

Copyright © 2018 Ammara Riaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Newman and G. M. Cragg, “Natural products as sources of new drugs over the 30 years from 1981 to 2010,” Journal of Natural Products, vol. 75, no. 75, pp. 311–335, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. D. G. Kingston, “Modern natural products drug discovery and its relevance to biodiversity conservation,” Journal of Natural Products, vol. 74, no. 74, pp. 496–511, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Veeresham, “Natural products derived from plants as a source of drugs,” Journal of Advanced Pharmaceutical Technology and Research, vol. 3, no. 3, pp. 200-201, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Katiyar, A. Gupta, S. Kanjilal, and S. Katiyar, “Drug discovery from plant sources: an integrated approach,” Ayu, vol. 33, no. 33, pp. 10–19, 2012. View at Publisher · View at Google Scholar
  5. A. L. Harvey, “Natural products in drug discovery,” Drug Discovery Today, vol. 13, no. 13, pp. 894–901, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Luo, R. E. Cobb, and H. Zhao, “Recent advances in natural product discovery,” Current Opinion in Biotechnology, vol. 30, no. 30, pp. 230–237, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Rasul, F. M. Millimouno, W. Ali Eltayb, M. Ali, J. Li, and X. Li, “Pinocembrin: a novel natural compound with versatile pharmacological and biological activities,” BioMed Research International, vol. 2013, Article ID 379850, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Hong, “Role of natural product diversity in chemical biology,” Current Opinion in Chemical Biology, vol. 15, no. 15, pp. 350–354, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. O. I. Aruoma, M. Grootveld, and T. Bahorun, “Free radicals in biology and medicine: from inflammation to biotechnology,” BioFactors, vol. 27, no. 27, pp. 1–3, 2006. View at Publisher · View at Google Scholar
  10. J. K. Prasain and S. Barnes, “Metabolism and bioavailability of flavonoids in chemoprevention: current analytical strategies and future prospectus,” Molecular Pharmaceutics, vol. 4, no. 4, pp. 846–864, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. P. Spencer, “Flavonoids: modulators of brain function?” British Journal of Nutrition, vol. 99, no. 1, pp. ES60–ES77, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Kotani, M. Matsumoto, A. Fujita et al., “Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice,” Journal of Allergy and Clinical Immunology, vol. 106, no. 106, pp. 159–166, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Bitis, S. Kultur, G. Melikoglu, N. Ozsoy, and A. Can, “Flavonoids and antioxidant activity of Rosa agrestis leaves,” Natural Product Research, vol. 24, no. 24, pp. 580–589, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. H. Kim, Y. J. Choi, M. K. Kang et al., “Astragalin inhibits allergic inflammation and airway thickening in ovalbumin-challenged mice,” Journal of Agricultural and Food Chemistry, vol. 65, no. 65, pp. 836–845, 2017. View at Publisher · View at Google Scholar · View at Scopus
  15. O. Burmistrova, J. Quintana, J. G. Diaz, and F. Estevez, “Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway,” Cancer Letters, vol. 309, no. 309, pp. 71–77, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. R. Bainey and P. W. Armstrong, “Clinical perspectives on reperfusion injury in acute myocardial infarction,” American Heart Journal, vol. 167, no. 167, pp. 637–645, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. L. Yang, Q. Chen, F. Wang, and G. Zhang, “Antiosteoporotic compounds from seeds of Cuscuta chinensis,” Journal of Ethnopharmacology, vol. 135, no. 135, pp. 553–560, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Donnapee, J. Li, X. Yang et al., “Cuscuta chinensis Lam.: a systematic review on ethnopharmacology, phytochemistry and pharmacology of an important traditional herbal medicine,” Journal of Ethnopharmacology, vol. 157, no. 157, pp. 292–308, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Saito, G. Silva, R. X. Santos, G. Gosmann, C. Pungartnik, and M. Brendel, “Astragalin from Cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast Saccharomyces cerevisiae,” International Journal of Molecular Sciences, vol. 13, no. 13, pp. 2846–2862, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Pei, P. Dong, T. Wu et al., “Metabolic engineering of Escherichia coli for astragalin biosynthesis,” Journal of Agricultural and Food Chemistry, 2016, In Press. View at Google Scholar
  21. X. Z. Huang, L. X. Tan, K. Gu, and C. Li, “Studies on chemical constituents from leaves of Acer truncatum,” China Journal of Chinese Materia Medica, vol. 32, no. 32, pp. 1544–1546, 2007. View at Google Scholar
  22. J. T. Han, M. H. Bang, O. K. Chun, D. O. Kim, C. Y. Lee, and N. I. Baek, “Flavonol glycosides from the aerial parts of Aceriphyllum rossii and their antioxidant activities,” Archives of Pharmacal Research, vol. 27, no. 27, pp. 390–395, 2004. View at Publisher · View at Google Scholar
  23. H. Kato, W. Li, M. Koike, Y. Wang, and K. Koike, “Phenolic glycosides from Agrimonia pilosa,” Phytochemistry, vol. 71, no. 71, pp. 1925–1929, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Ivanova, B. Mikhova, H. Najdenski, I. Tsvetkova, and I. Kostova, “Chemical composition and antimicrobial activity of wild garlic Allium ursinum of Bulgarian origin,” Natural Product Communications, vol. 4, no. 4, pp. 1059–1062, 2009. View at Google Scholar
  25. K. T. Lee, J. H. Choi, D. H. Kim et al., “Constituents and the antitumor principle of Allium victorialis var. platyphyllum,” Archives of Pharmacal Research, vol. 24, no. 24, pp. 44–50, 2001. View at Publisher · View at Google Scholar
  26. H. C. Chiang, Y. J. Lo, and F. J. Lu, “Xanthine oxidase inhibitors from the leaves of Alsophila spinulosa (Hook) Tryon,” Journal of Enzyme Inhibition, vol. 8, no. 8, pp. 61–71, 1994. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Zhang, C. Liu, Z. Zhang, J. Wang, G. Wu, and S. Li, “Comprehensive separation and identification of chemical constituents from Apocynum venetum leaves by high-performance counter-current chromatography and high performance liquid chromatography coupled with mass spectrometry,” Journal of Chromatography B, vol. 878, no. 878, pp. 3149–3155, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. N. T. Huong, N. K. Cu, T. V. Quy, C. Zidorn, M. Ganzera, and H. Stuppner, “A new phenylpropanoid glycoside from Jasminum subtriplinerve Blume,” Journal of Asian Natural Products Research, vol. 10, no. 10, pp. 1035–1038, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. I. Krasteva, S. Platikanov, S. Nikolov, and M. Kaloga, “Flavonoids from Astragalus hamosus,” Natural Product Research, vol. 21, no. 21, pp. 392–395, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. P. V. Kiem, C. V. Minh, H. T. Huong, J. J. Lee, and Y. H. Kim, “Caesaldecan, a cassane diterpenoid from the leaves of Caesalpinia decapetala,” Chemical and Pharmaceutical Bulletin, vol. 53, no. 53, pp. 428–430, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Ahmed, A. Moawad, A. Owis, S. AbouZid, and O. Ahmed, “Flavonoids of Calligonum polygonoides and their cytotoxicity,” Pharmaceutical Biology, vol. 54, no. 54, pp. 2119–2126, 2016. View at Publisher · View at Google Scholar · View at Scopus
  32. D. W. Chung and S. B. Lee, “Novel synthesis of leucoside by enzymatic hydrolysis of tea seed extract,” Journal of the Science of Food and Agriculture, vol. 93, no. 93, pp. 362–367, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. H. B. Lee, E. K. Kim, S. J. Park, S. G. Bang, T. G. Kim, and D. W. Chung, “Isolation and anti-inflammatory effect of astragalin synthesized by enzymatic hydrolysis of tea seed extract,” Journal of the Science of Food and Agriculture, vol. 91, no. 91, pp. 2315–2321, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. H. B. Lee, E. K. Kim, S. J. Park, S. G. Bang, T. G. Kim, and D. W. Chung, “Isolation and characterization of nicotiflorin obtained by enzymatic hydrolysis of two precursors in tea seed extract,” Journal of Agricultural and Food Chemistry, vol. 58, no. 58, pp. 4808–4813, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. Z. M. Luo, T. J. Ling, L. X. Li et al., “A new norisoprenoid and other compounds from Fuzhuan brick tea,” Molecules, vol. 17, no. 17, pp. 3539–3546, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. W. S. Feng, Z. Y. Hao, X. K. Zheng, and H. X. Kuang, “Chemical constituents from leaves of Celastrus gemmatus Loes,” Acta Pharmaceutica Sinica, vol. 42, no. 42, pp. 625–630, 2007. View at Google Scholar
  37. N. X. Nhiem, B. H. Tai, T. H. Quang et al., “A new ursane-type triterpenoid glycoside from Centella asiatica leaves modulates the production of nitric oxide and secretion of TNF-α in activated RAW 264.7 cells,” Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 21, pp. 1777–1781, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. H. Van Oanh, P. X. Sinh, N. T. An et al., “A new rearranged abietane diterpene and other constituents from Clerodendrum philipinum,” Natural Product Communications, vol. 4, no. 4, pp. 323–325, 2009. View at Google Scholar
  39. F. Calzada, R. Cedillo-Rivera, and R. Mata, “Antiprotozoal activity of the constituents of Conyza filaginoides,” Journal of Natural Products, vol. 64, no. 64, pp. 671–673, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Yoshikawa, H. Shimada, M. Saka, S. Yoshizumi, J. Yamahara, and H. Matsuda, “Medicinal foodstuffs. V. Moroheiya. (1): absolute stereostructures of corchoionosides A, B, and C, histamine release inhibitors from the leaves of Vietnamese Corchorus olitorius L. (Tiliaceae),” Chemical and Pharmaceutical Bulletin, vol. 45, no. 45, pp. 464–469, 1997. View at Publisher · View at Google Scholar
  41. M. Ye, Y. Yan, and D. A. Guo, “Characterization of phenolic compounds in the Chinese herbal drug Tu-Si-Zi by liquid chromatography coupled to electrospray ionization mass spectrometry,” Rapid Communications in Mass Spectrometry, vol. 19, no. 19, pp. 1469–1484, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. H. Guo and J. Li, “Flavonoids of Cuscuta australis R. Br,” China Journal of Chinese Materia Medica, vol. 22, no. 22, pp. 38-39, 1997. View at Google Scholar
  43. X. He, W. Yang, M. Ye, Q. Wang, and D. Guo, “Differentiation of Cuscuta chinensis and Cuscuta australis by HPLC-DAD-MS analysis and HPLC-UV quantitation,” Planta Medica, vol. 77, no. 77, pp. 1950–1957, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. J. H. Lee, C. H. Ku, N. I. Baek, S. H. Kim, H. W. Park, and D. K. Kim, “Phytochemical constituents from Diodia teres,” Archives of Pharmacal Research, vol. 27, no. 27, pp. 40–43, 2004. View at Publisher · View at Google Scholar
  45. C. Braunberger, M. Zehl, J. Conrad et al., “LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata,” Journal of Chromatography B, vol. 932, no. 932, pp. 111–116, 2013. View at Publisher · View at Google Scholar · View at Scopus
  46. G. A. Cordell, R. L. Lyon, H. H. Fong, P. S. Benoit, and N. R. Farnsworth, “Biological and phytochemical investigations of Dianthus barbatus cv. “China Doll” (Caryophyllaceae),” Lloydia, vol. 40, no. 40, pp. 361–363, 1977. View at Google Scholar
  47. H. Y. Kim, B. H. Moon, H. J. Lee, and D. H. Choi, “Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity,” Journal of Ethnopharmacology, vol. 93, no. 93, pp. 227–230, 2004. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Cheng, Y. Y. Zhao, Y. X. Cui, and T. M. Cheng, “Studies on flavonoids from leave of Eucommia ulmoides Oliv,” China Journal of Chinese Materia Medica, vol. 25, no. 25, pp. 284–286, 2000. View at Google Scholar
  49. X. Li, Z. Tang, D. Fei, Y. Liu, M. Zhang, and S. Liu, “Evaluation of the sedative and hypnotic effects of astragalin isolated from Eucommia ulmoides leaves in mice,” Natural Product Research, vol. 31, no. 31, pp. 2072–2076, 2017. View at Publisher · View at Google Scholar · View at Scopus
  50. E. T. Elema, J. Schripsema, and T. M. Malingre, “Flavones and flavonol glycosides from Eupatorium cannabinum L,” Pharmaceutisch Weekblad. Scientific Edition, vol. 11, no. 11, pp. 161–164, 1989. View at Publisher · View at Google Scholar · View at Scopus
  51. S. H. Qian, N. Y. Yang, J. A. Duan, L. H. Yuan, and L. J. Tian, “Study on the flavonoids of Eupatorium lindleyanum,” China Journal of Chinese Materia Medica, vol. 29, no. 29, pp. 50–52, 2004. View at Google Scholar
  52. J. Zhang, X. Li, L. Ren, C. Fang, and F. Wang, “Chemical constituents from Exochorda racemosa,” China Journal of Chinese Materia Medica, vol. 36, no. 36, pp. 1198–1201, 2011. View at Google Scholar
  53. Q. Xie, L. Ding, Y. Wei, and Y. Ito, “Determination of major components and fingerprint analysis of Flaveria bidentis (L.) Kuntze,” Journal of Chromatographic Science, vol. 52, no. 52, pp. 252–257, 2014. View at Publisher · View at Google Scholar · View at Scopus
  54. Y. Wei, Q. Xie, D. Fisher, and I. A. Sutherland, “Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography,” Journal of chromatography A, vol. 1218, pp. 6206–6211, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. Y. Yang, Y. Zhao, D. Gu et al., “Separation of the minor flavonols from Flos Gossypii by high-speed countercurrent chromatography,” Journal of Liquid Chromatography and Related Technologies, vol. 33, no. 33, pp. 1502–1515, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. Z. G. Tai, X. Q. Yang, L. Cai, W. J. Sun, Z. T. Ding, and Y. B. Yang, “Studies on the chemical constituents from the aerial parts of Gladiolus gandavensis,” Journal of Chinese Medicinal Materials, vol. 33, no. 33, pp. 1257–1259, 2010. View at Google Scholar
  57. D. M. Biondi, C. Rocco, and G. Ruberto, “Dihydrostilbene derivatives from Glycyrrhiza glabra leaves,” Journal of Natural Products, vol. 68, no. 68, pp. 1099–1102, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. S. S. Jia, C. M. Ma, Y. H. Li, and J. H. Hao, “Glycosides of phenolic acid and flavonoids from the leaves of Glycyrrhiza uralensis Ficsh,” Acta Pharmaceutica Sinica, vol. 27, no. 27, pp. 441–444, 1992. View at Google Scholar
  59. K. Algariri, K. Y. Meng, I. J. Atangwho et al., “Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts,” Asian Pacific Journal of Tropical Biomedicine, vol. 3, no. 3, pp. 358–366, 2013. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Trute and A. Nahrstedt, “Identification and quantitative analysis of phenolic compounds from the dry extract of Hedera helix,” Planta Medica, vol. 63, no. 63, pp. 177–179, 1997. View at Publisher · View at Google Scholar
  61. F. Calzada and A. D. Alanis, “Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum,” Phytotherapy Research, vol. 21, no. 21, pp. 78–80, 2007. View at Publisher · View at Google Scholar · View at Scopus
  62. Y. L. Ren and J. S. Yang, “Study on chemical constituents of Hemistepta lyrata Bunge,” Acta Pharmaceutica Sinica, vol. 36, no. 36, pp. 746–749, 2001. View at Google Scholar
  63. M. Heinaaho, J. Pusenius, and R. Julkunen-Tiitto, “Effects of different organic farming methods on the concentration of phenolic compounds in sea buckthorn leaves,” Journal of Agricultural and Food Chemistry, vol. 54, no. 54, pp. 7678–7685, 2006. View at Publisher · View at Google Scholar · View at Scopus
  64. J. G. Luo and L. Y. Kong, “Study on flavonoids from leaf of Ipomoea batatas,” China Journal of Chinese Materia Medica, vol. 30, no. 30, pp. 516–518, 2005. View at Google Scholar
  65. Q. H. Qu, L. Zhang, H. Bao, J. H. Zhang, X. J. You, and J. X. Wang, “Chemical constituents of flavonoids from flowers of Koelreuteria paniculata,” Journal of Chinese Medicinal Materials, vol. 34, no. 34, pp. 1716–1719, 2011. View at Google Scholar
  66. N. Bernaert, D. Wouters, L. De Vuyst et al., “Antioxidant changes of leek (Allium ampeloprasum var. porrum) during spontaneous fermentation of the white shaft and green leaves,” Journal of the Science of Food and Agriculture, vol. 93, no. 93, pp. 2146–2153, 2013. View at Publisher · View at Google Scholar · View at Scopus
  67. D. C. Ren, N. Y. Yang, S. H. Qian, N. Xie, X. M. Zhou, and J. A. Duan, “Chemical study on aerial parts of Ligusticum chuanxiong,” China Journal of Chinese Materia Medica, vol. 32, no. 32, pp. 1418–1420, 2007. View at Google Scholar
  68. M. Xiao, N. Cao, J. J. Fan, Y. Shen, and Q. Xu, “Studies on flavonoids from the leaves of Lindera aggregata,” Journal of Chinese Medicinal Materials, vol. 34, no. 34, pp. 62–64, 2011. View at Google Scholar
  69. H. Ye and J. Yu, “The preliminary studies on antioxidation of three kinds of flavoniods from Litsea coreana,” Journal of Chinese Medicinal Materials, vol. 27, no. 27, pp. 113–115, 2004. View at Google Scholar
  70. K. Y. Jung, S. R. Oh, S. H. Park et al., “Anti-complement activity of tiliroside from the flower buds of Magnolia fargesii,” Biological and Pharmaceutical Bulletin, vol. 21, no. 21, pp. 1077-1078, 1998. View at Publisher · View at Google Scholar · View at Scopus
  71. B. Vongsak, P. Sithisarn, and W. Gritsanapan, “Simultaneous HPLC quantitative analysis of active compounds in leaves of Moringa oleifera Lam,” Journal of Chromatographic Science, vol. 52, no. 52, pp. 641–645, 2014. View at Publisher · View at Google Scholar · View at Scopus
  72. K. Doi, T. Kojima, M. Makino, Y. Kimura, and Y. Fujimoto, “Studies on the constituents of the leaves of Morus alba L,” Chemical and Pharmaceutical Bulletin, vol. 49, no. 49, pp. 151–153, 2001. View at Publisher · View at Google Scholar · View at Scopus
  73. M. Sugiyama, T. Katsube, A. Koyama, and H. Itamura, “Varietal differences in the flavonol content of mulberry (Morus spp.) leaves and genetic analysis of quercetin 3-(6-malonylglucoside) for component breeding,” Journal of Agricultural and Food Chemistry, vol. 61, no. 61, pp. 9140–9147, 2013. View at Publisher · View at Google Scholar · View at Scopus
  74. J. He, Y. Feng, H. Z. Ouyang et al., “A sensitive LC-MS/MS method for simultaneous determination of six flavonoids in rat plasma: application to a pharmacokinetic study of total flavonoids from mulberry leaves,” Journal of Pharmaceutical and Biomedical Analysis, vol. 84, no. 84, pp. 189–195, 2013. View at Publisher · View at Google Scholar · View at Scopus
  75. J. Choi, H. J. Kang, S. Z. Kim, T. O. Kwon, S. I. Jeong, and S. I. Jang, “Antioxidant effect of astragalin isolated from the leaves of Morus alba L. against free radical-induced oxidative hemolysis of human red blood cells,” Archives of Pharmacal Research, vol. 36, no. 36, pp. 912–917, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. Y. Zou, S. Liao, W. Shen et al., “Phenolics and antioxidant activity of mulberry leaves depend on cultivar and harvest month in Southern China,” International Journal of Molecular Sciences, vol. 13, no. 13, pp. 16544–16553, 2012. View at Publisher · View at Google Scholar · View at Scopus
  77. Y. Tao, Y. Zhang, Y. Cheng, and Y. Wang, “Rapid screening and identification of alpha-glucosidase inhibitors from mulberry leaves using enzyme-immobilized magnetic beads coupled with HPLC/MS and NMR,” Biomedical Chromatography, vol. 27, no. 27, pp. 148–155, 2013. View at Publisher · View at Google Scholar · View at Scopus
  78. S. Y. Kim, J. J. Gao, W. C. Lee, K. S. Ryu, K. R. Lee, and Y. C. Kim, “Antioxidative flavonoids from the leaves of Morus alba,” Archives of Pharmacal Research, vol. 22, no. 22, pp. 81–85, 1999. View at Publisher · View at Google Scholar
  79. Y. Ranarivelo, A. L. Skaltsounis, M. Andriantsiferana, and F. Tillequin, “Glycosides from Mussaenda arcuata Lam. ex Poiret leaves,” Annales Pharmaceutiques Francaises, vol. 48, no. 48, pp. 273–277, 1990. View at Google Scholar
  80. E. Ohkoshi, H. Miyazaki, K. Shindo, H. Watanabe, A. Yoshida, and H. Yajima, “Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice,” Planta Medica, vol. 73, no. 73, pp. 1255–1259, 2007. View at Publisher · View at Google Scholar · View at Scopus
  81. N. Tian, Z. Liu, J. Huang, G. Luo, S. Liu, and X. Liu, “Isolation and preparation of flavonoids from the leaves of Nelumbo nucifera Gaertn by preparative reversed-phase high performance liquid chromatography,” Chinese Journal of Chromatography, vol. 25, no. 25, pp. 88–92, 2007. View at Google Scholar
  82. X. L. Zhao, Z. M. Wang, X. J. Ma, W. G. Jing, and A. Liu, “Chemical constituents from leaves of Nelumbo nucifera,” China Journal of Chinese Materia Medica, vol. 38, no. 38, pp. 703–708, 2013. View at Google Scholar
  83. S. Xu, Y. Sun, F. Jing, W. Duan, J. Du, and X. Wang, “Separation and purification of flavones from Nelumbo nucifera Gaertn. by silica gel chromatography and high-speed counter-current chromatography,” Chinese Journal of Chromatography, vol. 29, no. 29, pp. 1244–1248, 2011. View at Google Scholar
  84. S. Deng, Z. Deng, Y. Fan et al., “Isolation and purification of three flavonoid glycosides from the leaves of Nelumbo nucifera (Lotus) by high-speed counter-current chromatography,” Journal of chromatography B, vol. 877, no. 877, pp. 2487–2492, 2009. View at Publisher · View at Google Scholar · View at Scopus
  85. H. H. Barakat, A. M. El-Mousallamy, A. M. Souleman, and S. Awadalla, “Flavonoids of Ochradenus baccatus,” Phytochemistry, vol. 30, no. 30, pp. 3777–3779, 1991. View at Publisher · View at Google Scholar · View at Scopus
  86. C. Je Ma, W. J. Jung, K. Y. Lee, Y. C. Kim, and S. H. Sung, “Calpain inhibitory flavonoids isolated from Orostachys japonicus,” Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 24, no. 24, pp. 676–679, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. M. Matsumoto, M. Kotani, A. Fujita et al., “Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga,” British Journal of Dermatology, vol. 146, no. 146, pp. 221–227, 2002. View at Publisher · View at Google Scholar · View at Scopus
  88. Y. L. Xue, T. Miyakawa, Y. Hayashi et al., “Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki,” Journal of Agricultural and Food Chemistry, vol. 59, no. 59, pp. 6011–6017, 2011. View at Publisher · View at Google Scholar · View at Scopus
  89. K. Kameda, T. Takaku, H. Okuda et al., “Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity,” Journal of Natural Products, vol. 50, no. 50, pp. 680–683, 1987. View at Publisher · View at Google Scholar · View at Scopus
  90. Z. Ma, T. Piao, Y. Wang, and J. Liu, “Astragalin inhibits IL-1β-induced inflammatory mediators production in human osteoarthritis chondrocyte by inhibiting NF-κB and MAPK activation,” International Immunopharmacology, vol. 25, no. 25, pp. 83–87, 2015. View at Publisher · View at Google Scholar · View at Scopus
  91. F. Li, W. Wang, Y. Cao et al., “Inhibitory effects of astragalin on lipopolysaccharide-induced inflammatory response in mouse mammary epithelial cells,” Journal of Surgical Research, vol. 192, no. 192, pp. 573–581, 2014. View at Publisher · View at Google Scholar · View at Scopus
  92. F. Li, D. Liang, Z. Yang et al., “Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model,” International Immunopharmacology, vol. 17, no. 17, pp. 478–482, 2013. View at Publisher · View at Google Scholar · View at Scopus
  93. K. Skalicka-Wozniak, J. Szypowski, and K. Glowniak, “HPLC analysis of kaempherol and quercetin derivatives isolated by different extraction techniques from plant matrix,” Journal of AOAC International, vol. 94, no. 94, pp. 17–21, 2011. View at Google Scholar
  94. J. M. Laparra, R. P. Glahn, and D. D. Miller, “Assessing potential effects of inulin and probiotic bacteria on Fe availability from common beans (Phaseolus vulgaris L.) to Caco-2 cells,” Journal of Food Science, vol. 74, no. 74, pp. H40–H46, 2009. View at Publisher · View at Google Scholar · View at Scopus
  95. Y. Takeda, N. Isai, T. Masuda et al., “Phlomisflavosides A and B, new flavonol bisglycosides from Phlomis spinidens,” Chemical and Pharmaceutical Bulletin, vol. 49, no. 49, pp. 1039–1041, 2001. View at Publisher · View at Google Scholar · View at Scopus
  96. C. Agyare, M. Lechtenberg, A. Deters, F. Petereit, and A. Hensel, “Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts,” Phytomedicine, vol. 18, no. 18, pp. 617–624, 2011. View at Publisher · View at Google Scholar · View at Scopus
  97. L. C. Klein-Junior, J. R. Santin, M. Lemos et al., “Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by Polygala cyparissias (Polygalaceae) in mice,” Journal of Pharmacy and Pharmacology, vol. 65, no. 65, pp. 767–776, 2013. View at Publisher · View at Google Scholar · View at Scopus
  98. I. Calis, A. Kuruuzum, L. O. Demirezer, O. Sticher, W. Ganci, and P. Ruedi, “Phenylvaleric acid and flavonoid glycosides from Polygonum salicifolium,” Journal of Natural Products, vol. 62, no. 62, pp. 1101–1105, 1999. View at Publisher · View at Google Scholar · View at Scopus
  99. M. A. Olszewska and A. Kwapisz, “Metabolite profiling and antioxidant activity of Prunus padus L. flowers and leaves,” Natural Product Research, vol. 25, no. 25, pp. 1115–1131, 2011. View at Publisher · View at Google Scholar · View at Scopus
  100. M. Olszewska, “High-performance liquid chromatographic identification of flavonoid monoglycosides from Prunus serotina ehrh,” Acta Poloniae Pharmaceutica, vol. 62, no. 62, pp. 435–441, 2005. View at Google Scholar
  101. M. Krauze-Baranowska, P. Sowinski, A. Kawiak, and B. Sparzak, “Flavonoids from Pseudotsuga menziesii,” Journal of Biosciences, vol. 68, no. 68, pp. 87–96, 2013. View at Publisher · View at Google Scholar
  102. H. J. Kwon and Y. D. Park, “Determination of astragalin and astragaloside content in Radix astragali using high-performance liquid chromatography coupled with pulsed amperometric detection,” Journal of Chromatography A, vol. 1232, pp. 212–217, 2012. View at Publisher · View at Google Scholar · View at Scopus
  103. J. Jian and Z. Wu, “Influences of traditional Chinese medicine on non-specific immunity of Jian Carp (Cyprinus carpio var. Jian),” Fish and Shellfish Immunology, vol. 16, no. 16, pp. 185–191, 2004. View at Publisher · View at Google Scholar · View at Scopus
  104. G. Li, T. Gao, J. Wen, R. Yang, C. Yu, and S. Zhang, “A research on the quality of radix Astragali,” China Journal of Chinese Materia Medica, vol. 17, no. 17, pp. 454–456, 1992. View at Google Scholar
  105. Y. Ding, H. T. Nguyen, E. M. Choi, K. Bae, and Y. H. Kim, “Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 cells,” Planta Medica, vol. 75, no. 75, pp. 158–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  106. C. Yang, F. Li, X. Zhang, L. Wang, Z. Zhou, and M. Wang, “Phenolic antioxidants from Rosa soulieana flowers,” Natural Product Research, vol. 27, no. 27, pp. 2055–2058, 2013. View at Publisher · View at Google Scholar · View at Scopus
  107. T. B. Nguelefack, F. H. Mbakam, L. A. Tapondjou et al., “A dimeric triterpenoid glycoside and flavonoid glycosides with free radical-scavenging activity isolated from Rubus rigidus var. camerunensis,” Archives of Pharmacal Research, vol. 34, no. 34, pp. 543–550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  108. H. Q. Wang, C. Y. Zhao, and R. Y. Chen, “Studies on chemical constituents from leaves of Sapium sebiferum,” China Journal of Chinese Materia Medica, vol. 32, no. 32, pp. 1179–1181, 2007. View at Google Scholar
  109. M. S. Kamel, K. Ohtani, H. A. Hasanain, M. H. Mohamed, R. Kasai, and K. Yamasaki, “Monoterpene and pregnane glucosides from Solenostemma argel,” Phytochemistry, vol. 53, no. 53, pp. 937–940, 2000. View at Publisher · View at Google Scholar · View at Scopus
  110. P. Apati, P. J. Houghton, and A. Kery, “HPLC investigation of antioxidant components in Solidago herba,” Acta Pharmaceutica Hungarica, vol. 74, no. 74, pp. 223–231, 2004. View at Google Scholar
  111. M. A. Olszewska and P. Michel, “Activity-guided isolation and identification of free radical-scavenging components from various leaf extracts of Sorbus aria (L.) Crantz,” Natural Product Research, vol. 26, no. 26, pp. 243–254, 2012. View at Publisher · View at Google Scholar · View at Scopus
  112. W. Xiang, R. T. Li, Y. L. Mao et al., “Four new prenylated isoflavonoids in Tadehagi triquetrum,” Journal of Agricultural and Food Chemistry, vol. 53, no. 53, pp. 267–271, 2005. View at Publisher · View at Google Scholar · View at Scopus
  113. G. Shen, S. R. Oh, B. S. Min et al., “Phytochemical investigation of Tiarella polyphylla,” Archives of Pharmacal Research, vol. 31, no. 31, pp. 10–16, 2008. View at Publisher · View at Google Scholar · View at Scopus
  114. S. Hosoi, E. Shimizu, K. Ohno et al., “Structural studies of zoospore attractants from Trachelospermum jasminoides var. pubescens: taxifolin 3-O-glycosides,” Phytochemical Analysis, vol. 17, no. 17, pp. 20–24, 2006. View at Publisher · View at Google Scholar · View at Scopus
  115. H. Aishan, M. Baba, N. Iwasaki, H. Kuang, and T. Okuyama, “The constituents of Urtica cannabina used in Uighur medicine,” Pharmaceutical Biology, vol. 48, no. 48, pp. 577–583, 2010. View at Publisher · View at Google Scholar · View at Scopus
  116. R. R. Majinda, M. Motswaledi, R. D. Waigh, and P. G. Waterman, “Phenolic and antibacterial constituents of Vahlia capensis,” Planta Medica, vol. 63, no. 63, pp. 268–270, 1997. View at Publisher · View at Google Scholar · View at Scopus
  117. A. N. Singab, D. T. Youssef, E. Noaman, and S. Kotb, “Hepatoprotective effect of flavonol glycosides rich fraction from Egyptian Vicia calcarata Desf. against CCl4-induced liver damage in rats,” Archives of Pharmacal Research, vol. 28, no. 28, pp. 791–798, 2005. View at Publisher · View at Google Scholar · View at Scopus
  118. S. Apers, Y. Huang, S. Van Miert et al., “Characterisation of new oligoglycosidic compounds in two Chinese medicinal herbs,” Phytochemical Analysis, vol. 13, no. 13, pp. 202–206, 2002. View at Publisher · View at Google Scholar · View at Scopus
  119. U. Weiss, “Inflammation,” Nature, vol. 454, no. 454, p. 427, 2008. View at Publisher · View at Google Scholar · View at Scopus
  120. I. Sarfraz, A. Rasul, F. Jabeen et al., “Fraxinus: a plant with versatile pharmacological and biological activities,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 4269868, 12 pages, 2017. View at Publisher · View at Google Scholar
  121. J. Walker, K. V. Reichelt, K. Obst et al., “Identification of an anti-inflammatory potential of Eriodictyon angustifolium compounds in human gingival fibroblasts,” Food and Function, vol. 7, no. 7, pp. 3046–3055, 2016. View at Publisher · View at Google Scholar · View at Scopus
  122. L. W. Soromou, N. Chen, L. Jiang et al., “Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway,” Biochemical and Biophysical Research Communications, vol. 419, no. 419, pp. 256–261, 2012. View at Publisher · View at Google Scholar · View at Scopus
  123. E. J. Choi, S. Lee, J. R. Chae, H. S. Lee, C. D. Jun, and S. H. Kim, “Eupatilin inhibits lipopolysaccharide-induced expression of inflammatory mediators in macrophages,” Life Sciences, vol. 88, no. 88, pp. 1121–1126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  124. W. Zhang, X. Lu, W. Wang et al., “Inhibitory effects of emodin, thymol, and astragalin on leptospira interrogans-induced inflammatory response in the uterine and endometrium epithelial cells of mice,” Inflammation, vol. 40, no. 40, pp. 666–675, 2017. View at Publisher · View at Google Scholar · View at Scopus
  125. H. Inaba, M. Tagashira, D. Honma et al., “Identification of hop polyphenolic components which inhibit prostaglandin E2 production by gingival epithelial cells stimulated with periodontal pathogen,” Biological and Pharmaceutical Bulletin, vol. 31, no. 31, pp. 527–530, 2008. View at Publisher · View at Google Scholar · View at Scopus
  126. J. Liu, Y. Cheng, X. Zhang et al., “Astragalin attenuates allergic inflammation in a murine asthma model,” Inflammation, vol. 38, no. 38, pp. 2007–2016, 2015. View at Publisher · View at Google Scholar · View at Scopus
  127. M. S. Kim and S. H. Kim, “Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages,” Archives of Pharmacal Research, vol. 34, no. 34, pp. 2101–2107, 2011. View at Publisher · View at Google Scholar · View at Scopus
  128. Z. Wang, Q. Li, M. Xiang et al., “Astragaloside alleviates hepatic fibrosis function via PAR2 signaling pathway in diabetic rats,” Cellular Physiology and Biochemistry, vol. 41, no. 41, pp. 1156–1166, 2017. View at Publisher · View at Google Scholar · View at Scopus
  129. I. H. Cho, J. H. Gong, M. K. Kang et al., “Astragalin inhibits airway eotaxin-1 induction and epithelial apoptosis through modulating oxidative stress-responsive MAPK signaling,” BMC Pulmonary Medicine, vol. 14, no. 14, p. 122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  130. H. Li, R. Shi, F. Ding et al., “Astragalus polysaccharide suppresses 6-hydroxydopamine-induced neurotoxicity in Caenorhabditis elegans,” Oxidative Medicine and Cellular Longevity, vol. 2016, p. 4856761, 2016. View at Publisher · View at Google Scholar · View at Scopus
  131. L. Yan and Q. H. Zhou, “Study on neuroprotective effects of astragalan in rats with ischemic brain injury and its mechanisms,” Chinese Journal of Applied Physiology, vol. 28, no. 28, pp. 373–377, 2012. View at Google Scholar
  132. I. H. Cho, Y. J. Choi, J. H. Gong, D. Shin, M. K. Kang, and Y. H. Kang, “Astragalin inhibits autophagy-associated airway epithelial fibrosis,” Respiratory Research, vol. 16, no. 16, p. 51, 2015. View at Publisher · View at Google Scholar · View at Scopus
  133. A. Wasik and L. Antkiewicz-Michaluk, “The mechanism of neuroprotective action of natural compounds,” Pharmacological Reports, vol. 69, no. 69, pp. 851–860, 2017. View at Publisher · View at Google Scholar · View at Scopus
  134. A. Habertheuer, A. Kocher, G. Laufer et al., “Cardioprotection: a review of current practice in global ischemia and future translational perspective,” BioMed Research International, vol. 2014, Article ID 325725, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  135. K. Tanaka, J. R. Kersten, and M. L. Riess, “Opioid-induced cardioprotection,” Current Pharmaceutical Design, vol. 20, no. 20, pp. 5696–5705, 2014. View at Publisher · View at Google Scholar · View at Scopus
  136. L. Testai, “Flavonoids and mitochondrial pharmacology: A new paradigm for cardioprotection,” Life Sciences, vol. 135, no. 135, pp. 68–76, 2015. View at Publisher · View at Google Scholar · View at Scopus
  137. D. Qu, J. Han, H. Ren et al., “Cardioprotective effects of astragalin against myocardial ischemia/reperfusion injury in isolated rat heart,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 8194690, 11 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  138. S. Wang, N. Moustaid-Moussa, L. Chen et al., “Novel insights of dietary polyphenols and obesity,” Journal of Nutritional Biochemistry, vol. 25, no. 25, pp. 1–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  139. U. Alam, O. Asghar, S. Azmi, and R. A. Malik, “General aspects of diabetes mellitus,” Handbook of Clinical Neurology, vol. 126, no. 126, pp. 211–222, 2014. View at Publisher · View at Google Scholar · View at Scopus
  140. M. Jung, M. Park, H. C. Lee, Y. H. Kang, E. S. Kang, and S. K. Kim, “Antidiabetic agents from medicinal plants,” Current Medicinal Chemistry, vol. 13, no. 13, pp. 1203–1218, 2006. View at Publisher · View at Google Scholar · View at Scopus
  141. M. Ke, X. Q. Hu, J. Ouyang, B. Dai, and Y. Xu, “The effect of astragalin on the VEGF production of cultured Muller cells under high glucose conditions,” Bio-Medical Materials and Engineering, vol. 22, no. 22, pp. 113–119, 2012. View at Google Scholar
  142. G. E. Kim, H. K. Kang, E. S. Seo et al., “Glucosylation of the flavonoid, astragalin by Leuconostoc mesenteroides B-512FMCM dextransucrase acceptor reactions and characterization of the products,” Enzyme and Microbial Technology, vol. 50, no. 50, pp. 50–56, 2012. View at Publisher · View at Google Scholar · View at Scopus
  143. S. Y. Jung, W. S. Jung, H. K. Jung et al., “The mixture of different parts of Nelumbo nucifera and two bioactive components inhibited tyrosinase activity and melanogenesis,” Journal of Cosmetic Science, vol. 65, no. 65, pp. 377–388, 2014. View at Google Scholar
  144. A. Svobodova, J. Psotova, and D. Walterova, “Natural phenolics in the prevention of UV-induced skin damage. A review,” Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, vol. 147, no. 147, pp. 137–145, 2003. View at Publisher · View at Google Scholar · View at Scopus
  145. M. Chen, F. Cai, D. Zha et al., “Astragalin-induced cell death is caspase-dependent and enhances the susceptibility of lung cancer cells to tumor necrosis factor by inhibiting the NF-κB pathway,” Oncotarget, vol. 8, no. 8, pp. 26941–26958, 2017. View at Publisher · View at Google Scholar · View at Scopus
  146. M. Rasool, A. Malik, A. Manan et al., “Roles of natural compounds from medicinal plants in cancer treatment: structure and mode of action at molecular level,” Medicinal Chemistry, vol. 11, no. 11, pp. 618–628, 2015. View at Publisher · View at Google Scholar · View at Scopus
  147. V. S. Neergheen, T. Bahorun, E. W. Taylor, L. S. Jen, and O. I. Aruoma, “Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention,” Toxicology, vol. 278, no. 278, pp. 229–241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  148. S. Jafari, S. Saeidnia, and M. Abdollahi, “Role of natural phenolic compounds in cancer chemoprevention via regulation of the cell cycle,” Current Pharmaceutical Biotechnology, vol. 15, no. 15, pp. 409–421, 2014. View at Publisher · View at Google Scholar · View at Scopus
  149. J. Sun, F. Li, Y. Zhao et al., “LZ-207, a newly synthesized flavonoid, induces apoptosis and suppresses inflammation-related colon cancer by inhibiting the NF-κB signaling pathway,” PloS One, vol. 10, no. 10, Article ID e0127282, 2015. View at Publisher · View at Google Scholar · View at Scopus
  150. W. Li, J. Hao, L. Zhang, Z. Cheng, X. Deng, and G. Shu, “Astragalin reduces hexokinase 2 through increasing miR-125b to inhibit the proliferation of hepatocellular carcinoma cells in vitro and in vivo,” Journal of Agricultural and Food Chemistry, vol. 65, no. 65, pp. 5961–5972, 2017. View at Publisher · View at Google Scholar · View at Scopus
  151. O. H. You, E. A. Shin, H. Lee et al., “Apoptotic effect of astragalin in melanoma skin cancers via activation of caspases and inhibition of Sry-related HMg-box gene 10,” Phytotherapy Research, vol. 31, no. 31, pp. 1614–1620, 2017. View at Publisher · View at Google Scholar · View at Scopus
  152. J. Zhang, N. Li, K. Zhang et al., “Astragalin attenuates UVB radiation-induced actinic keratosis formation,” Anti-Cancer Agents in Medicinal Chemistry, 2017, In Press. View at Google Scholar
  153. Y. Y. Chiang, S. L. Wang, C. L. Yang et al., “Extracts of Koelreuteria henryi Dummer induce apoptosis and autophagy by inhibiting dihydrodiol dehydrogenase, thus enhancing anticancer effects,” International Journal of Molecular Medicine, vol. 32, no. 32, pp. 577–584, 2013. View at Publisher · View at Google Scholar · View at Scopus
  154. O. Ammar, “In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei,” Brazilian Journal of Pharmaceutical Sciences, vol. 53, no. 53, pp. 1–10, 2017. View at Publisher · View at Google Scholar · View at Scopus