Research Article

Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice

Figure 5

Oleander treatment for 20 consecutive days improves systemic metabolic homeostasis and antioxidant status. (a) The loading plot of principal component analysis (PCA) demonstrated a drastic shift of the spatial arrangement of T1D group mice from the remaining clusters. This was brought back to normal by glibenclamide and oleander treatment, spatial arrangement of which was near to control and far from T1D group. PC1 and PC2 accounted for cumulatively 88.2% and 81.8% variance, respectively. (b) The divergence of 5 different clusters of the 5 experimental groups were measured (Supplementary Materials) and represented using a dendrogram.
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