Current Status of Alginate in Drug Delivery

Table 3

Cell studies using alginate nano/microparticles.

Cell types	Polymer	Parameter study	Significant findings	References
Tumor therapeutic cells	Alginate	Encapsulation of cytotoxic compounds encapsulated into liposomes, micelles, and nanoparticles	Long-time release of nanoparticles in the brain parenchyma	[16]
Epithelial cells	Alginate	Physicochemical characteristics and biological properties of the airways	Solubility, lipophilicity, and therapeutic efficacy of microparticles; Shape, size, and density have an impact on the microparticles	[19]
Cell-dispersed collagen	Alginate	Microfluidic-based by anisotropic gelation of the capillary	Magnetic-responsive nanoparticles or cell-dispersed collagen for tissue scaffold was functionalized microsprings	[21]
Pancreatic rat islets	Alginates	Cell encapsulation by zwitterionic group	Alginates improved outcome of islet encapsulation in a chemically induced diabetic mouse model	[22]
Riboflavin	Sodium alginate and furfurylamine	Coupling and photo-crosslinked method	Photo-crosslinked F-alginate resulted in slow release and potential for cell growth enhancement for medical application, biomaterials, soft and hard tissue applications, and tissue interfaces	[102]