It may be concluded that supplementation with aqueous stem bark extract was useful in moderating the changes in liver, kidney, and serum variables of rats exposed to mycotoxins.
The methanolic stem bark extract, which reveals that prolonged use of the extract in the therapy of disease conditions may be related to some unfavourable effects on some essential organs.
All treatment groups had a substantial decrease in relative liver weight at when compared to the negative control. These findings imply that Detarium microcarpum stem bark contains antioxidant phytochemicals and may be useful in the treatment of liver damage.
The results of this experiment indicate that the fruit of D. microcarpum may have an adverse effect on rats and may include antinutrients that harm its digestion and absorption, resulting in the observed retardation of growth in rats.
The inclusion of the seeds in the diet, had no effect on the haematological and biochemical indicators at . Thus, tallow seed meal can be used in broiler chicken feeds up to 20% without affecting organ weight, haematological, or biochemical indices of broiler chickens.
Increased incorporation of seeds, reduced weight gain and FCR in a linear fashion. Birds fed 10%, 15%, and 20% diets had lower haematological and serum biochemical indices than those fed 5% and control diets at . Broiler chicks’ blood components were not adversely affected by the inclusion of 5% DSM in their diets. Processed DSM must be added to broiler meals to increase their incorporation levels above 5%.
It was shown that the LC50 for brine shrimp larvae was 158.49 g/mL for the methanolic extract of the stem bark. The results show that Detarium microcarpum is toxic and thus not safe, especially when administered in large doses without proper monitoring and management.
The chloroform and ethyl acetate extracts of D. microcarpum fruit pulp were the most cytotoxic to normal fibroblasts in a biocompatibility investigation of the fruit pulp. More than 80 percent of cells died when the hexane extract was applied at 500 g/mL, which was the highest concentration that was found to be cytotoxic. The cytotoxic effects of methanol extract were negligible.
Human lymphocytes were not harmed by the fruit pulp ethanol extract. The cytotoxicity of hydrogen peroxide and tert-butyl hydroperoxide to human lymphocytes was also dramatically lowered by pretreatment with fruit extracts. In terms of cytoprotective efficacy, both the extract and ascorbic acid were comparable at .
Mice died at concentrations of 2900 mg/Kg and 1600 mg/kg body weight from the methanolic stem bark extract, with an LD50 value of 3,807.89 mg/kg. Experiments with extracts of these plants have yielded a good dose guidance for an ongoing antimalarial study.
The fruit’s antioxidant molecules scavenging the hydroxyl radical, as well as the peroxyl and alkoxyl radicals produced by lipid peroxidation had a gene protective impact.
The oral LD50 of the extract was determined to be greater than 5000 mg/kg of body weight. There were no significant differences between the therapy groups when it came to renal function and haematological analysis.
