Table of Contents
Advances in Psychiatry
Volume 2015, Article ID 314804, 12 pages
http://dx.doi.org/10.1155/2015/314804
Research Article

The Effectiveness and Applicability of Compensatory Cognitive Training for Japanese Patients with Schizophrenia: A Pilot Study

1Department of Psychology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan
2Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan

Received 13 March 2015; Revised 14 June 2015; Accepted 16 June 2015

Academic Editor: Raphael J. Braga

Copyright © 2015 Sadao Otsuka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. M. Gold, “Cognitive deficits as treatment targets in schizophrenia,” Schizophrenia Research, vol. 72, no. 1, pp. 21–28, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. A.-K. J. Fett, W. Viechtbauer, M.-D. Dominguez, D. L. Penn, J. van Os, and L. Krabbendam, “The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis,” Neuroscience and Biobehavioral Reviews, vol. 35, no. 3, pp. 573–588, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. F. Green, “What are the functional consequences of neurocognitive deficits in schizophrenia?” American Journal of Psychiatry, vol. 153, no. 3, pp. 321–330, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. M. F. Green, R. S. Kern, D. L. Braff, and J. Mintz, “Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the ‘right stuff’?” Schizophrenia Bulletin, vol. 26, no. 1, pp. 119–136, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. M. F. Green, R. S. Kern, and R. K. Heaton, “Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS,” Schizophrenia Research, vol. 72, no. 1, pp. 41–51, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. K. H. Nuechterlein, K. L. Subotnik, M. F. Green et al., “Neurocognitive predictors of work outcome in recent-onset schizophrenia,” Schizophrenia Bulletin, vol. 37, supplement 2, pp. S33–S40, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. R. M. Bilder, R. S. Goldman, D. Robinson et al., “Neuropsychology of first-episode schizophrenia: initial characterization and clinical correlates,” American Journal of Psychiatry, vol. 157, no. 4, pp. 549–559, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. R. W. Heinrichs and K. K. Zakzanis, “Neurocognitive deficit in schizophrenia: a quantitative review of the evidence,” Neuropsychology, vol. 12, no. 3, pp. 426–445, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. R. I. Mesholam-Gately, A. J. Giuliano, K. P. Goff, S. V. Faraone, and L. J. Seidman, “Neurocognition in first-episode schizophrenia: a meta-analytic review,” Neuropsychology, vol. 23, no. 3, pp. 315–336, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Matsui, H. Yuuki, K. de Kato et al., “Schizotypal disorder and schizophrenia: a profile analysis of neuropsychological functioning in Japanese patients,” Journal of the International Neuropsychological Society, vol. 13, no. 4, pp. 672–682, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. W. J. Brewer, S. M. Francey, S. J. Wood et al., “Memory impairments identified in people at ultra-high risk for psychosis who later develop first-episode psychosis,” The American Journal of Psychiatry, vol. 162, no. 1, pp. 71–78, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. R. E. Carrión, T. E. Goldberg, D. McLaughlin, A. M. Auther, C. U. Correll, and B. A. Cornblatt, “Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis,” American Journal of Psychiatry, vol. 168, no. 8, pp. 806–813, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Jones, B. Rodgers, R. Murray, and M. Marmot, “Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort,” The Lancet, vol. 344, no. 8934, pp. 1398–1402, 1994. View at Publisher · View at Google Scholar · View at Scopus
  14. T. A. Niendam, C. E. Bearden, I. M. Rosso et al., “A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblings,” The American Journal of Psychiatry, vol. 160, no. 11, pp. 2060–2062, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. A. L. Hoff, C. Svetina, G. Shields, J. Stewart, and L. E. DeLisi, “Ten-year longitudinal study of neuropsychological functioning subsequent to a first episode of schizophrenia,” Schizophrenia Research, vol. 78, no. 1, pp. 27–34, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. C.-H. Lin, C.-L. Huang, Y.-C. Chang et al., “Clinical symptoms, mainly negative symptoms, mediate the influence of neurocognition and social cognition on functional outcome of schizophrenia,” Schizophrenia Research, vol. 146, no. 1–3, pp. 231–237, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Heydebrand, M. Weiser, J. Rabinowitz, A. L. Hoff, L. E. DeLisi, and J. G. Csernansky, “Correlates of cognitive deficits in first episode schizophrenia,” Schizophrenia Research, vol. 68, no. 1, pp. 1–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. D. S. O'Leary, M. Flaum, M. L. Kesler, L. A. Flashman, S. Arndt, and N. C. Andreasen, “Cognitive correlates of the negative, disorganized, and psychotic symptom dimensions of schizophrenia,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 12, no. 1, pp. 4–15, 2000. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Ventura, G. S. Hellemann, A. D. Thames, V. Koellner, and K. H. Nuechterlein, “Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis,” Schizophrenia Research, vol. 113, no. 2-3, pp. 189–199, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Ventura, K. L. Subotnik, A. Ered et al., “The relationship of attitudinal beliefs to negative symptoms, neurocognition, and daily functioning in recent-onset schizophrenia,” Schizophrenia Bulletin, vol. 40, no. 6, pp. 1308–1318, 2014. View at Publisher · View at Google Scholar
  21. M. Davidson, S. Galderisi, M. Weiser et al., “Cognitive effects of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: a randomized, open-label clinical trial (EUFEST),” American Journal of Psychiatry, vol. 166, no. 6, pp. 675–682, 2009. View at Publisher · View at Google Scholar
  22. R. S. E. Keefe, R. M. Bilder, S. M. Davis et al., “Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE trial,” Archives of General Psychiatry, vol. 64, no. 6, pp. 633–647, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. T. E. Goldberg, R. S. Goldman, K. E. Burdick et al., “Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?” Archives of General Psychiatry, vol. 64, no. 10, pp. 1115–1122, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Wykes, V. Huddy, C. Cellard, S. R. McGurk, and P. Czobor, “A meta-analysis of cognitive remediation for schizophrenia: methodology and effect sizes,” American Journal of Psychiatry, vol. 168, no. 5, pp. 472–485, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. S. R. McGurk, E. W. Twamley, D. I. Sitzer, G. J. McHugo, and K. T. Mueser, “A meta-analysis of cognitive remediation in schizophrenia,” The American Journal of Psychiatry, vol. 164, no. 12, pp. 1791–1802, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Ikezawa, T. Mogami, Y. Hayami et al., “The pilot study of a Neuropsychological Educational Approach to Cognitive Remediation for patients with schizophrenia in Japan,” Psychiatry Research, vol. 195, no. 3, pp. 107–110, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Matsui, H. Arai, M. Yonezawa, T. Sumiyoshi, M. Suzuki, and M. Kurachi, “The effects of cognitive rehabilitation on social knowledge in patients with schizophrenia,” Applied Neuropsychology, vol. 16, no. 3, pp. 158–164, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Pu, K. Nakagome, T. Yamada et al., “A pilot study on the effects of cognitive remediation on hemodynamic responses in the prefrontal cortices of patients with schizophrenia: a multi-channel near-infrared spectroscopy study,” Schizophrenia Research, vol. 153, no. 1–3, pp. 87–95, 2014. View at Publisher · View at Google Scholar
  29. S. Sato, K. Iwata, S.-I. Furukawa, Y. Matsuda, N. Hatsuse, and E. Ikebuchi, “The effects of the combination of cognitive training and supported employment on improving clinical and working outcomes for people with Schizophrenia in Japan,” Clinical Practice & Epidemiology in Mental Health, vol. 10, pp. 18–27, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. E. W. Twamley, G. N. Savla, C. H. Zurhellen, R. K. Heaton, and D. V. Jeste, “Development and pilot testing of a novel compensatory cognitive training intervention for people with psychosis,” The American Journal of Psychiatric Rehabilitation, vol. 11, no. 2, pp. 144–163, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. E. W. Twamley, L. Vella, C. Z. Burton, R. K. Heaton, and D. V. Jeste, “Compensatory cognitive training for psychosis: effects in a randomized controlled trial,” Journal of Clinical Psychiatry, vol. 73, no. 9, pp. 1212–1219, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Barlati, G. Deste, L. de Peri, C. Ariu, and A. Vita, “Cognitive remediation in schizophrenia: current status and future perspectives,” Schizophrenia Research and Treatment, vol. 2013, Article ID 156084, 12 pages, 2013. View at Publisher · View at Google Scholar
  33. A. Medalia and A. M. Saperstein, “Does cognitive remediation for schizophrenia improve functional outcomes?” Current Opinion in Psychiatry, vol. 26, no. 2, pp. 151–157, 2013. View at Publisher · View at Google Scholar · View at Scopus
  34. N. C. Andreasen, The Scale for the Assessment of Positive Symptoms (SAPS), The University of Iowa, Iowa City, Iowa, USA, 1984.
  35. N. C. Andreasen, The Scale for the Assessment of Negative Symptoms (SANS), The University of Iowa, Iowa City, Iowa, USA, 1983.
  36. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-4-TR), American Psychiatric Association, Washington, DC, USA, 2000.
  37. K. Matsuoka and Y. Kim, Japanese Adult Reading Test: JART, Shinkou Igaku Shuppan, Tokyo, Japan, 2006.
  38. A. Inagaki and T. Inada, “Dose equivalence of new psychotropic drugs—version 6: risperidone extended-release tablets,” Rinsyou Seishin Yakuri, vol. 15, no. 3, pp. 397–404, 2012 (Japanese). View at Google Scholar
  39. L. Clare, P. J. McKenna, A. M. Mortimer, and A. D. Baddeley, “Memory in schizophrenia: what is impaired and what is preserved?” Neuropsychologia, vol. 31, no. 11, pp. 1224–1241, 1993. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Kéri, A. Juhász, Á. Rimanóczy et al., “Habit learning and the genetics of the dopamine D3 receptor: evidence from patients with schizophrenia and healthy controls,” Behavioral Neuroscience, vol. 119, no. 3, pp. 687–693, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. P. J. Bayley, J. C. Frascino, and L. R. Squire, “Robust habit learning in the absence of awareness and independent of the medial temporal lobe,” Nature, vol. 436, no. 7050, pp. 550–553, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. S. R. McGurk and H. Y. Meltzer, “The role of cognition in vocational functioning in schizophrenia,” Schizophrenia Research, vol. 45, no. 3, pp. 175–184, 2000. View at Publisher · View at Google Scholar · View at Scopus
  43. W. Spaulding, D. Reed, D. Storzbach, M. Sullivan, M. Weiler, and C. Richardson, “The effects of a remediational approach to cognitive therapy for schizophrenia,” in Outcome and Innovation in Psychological Treatment of Schizophrenia, T. Wykes, N. Tarrier, and S. Lewis, Eds., pp. 145–160, John Wiley & Sons, London, UK, 1998. View at Google Scholar
  44. M. Matsui, H. Yuuki, K. Kato, and M. Kurachi, “Impairment of memory-organization in patients with schizophrenia or schizotypal disorder,” Journal of the International Neuropsychological Society, vol. 12, no. 5, pp. 750–754, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Matsui, T. Sumiyoshi, K. Kato, and M. Kurachi, “Development of alternate forms of Japanese verbal learning test,” Seishin Igaku, vol. 49, no. 1, pp. 31–34, 2007 (Japanese). View at Google Scholar
  46. J. M. Gold, C. Randolph, C. J. Carpenter, T. E. Goldberg, and D. R. Weinberger, “Forms of memory failure in schizophrenia,” Journal of Abnormal Psychology, vol. 101, no. 3, pp. 487–494, 1992. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Watamori, H. Hara, T. Miyamori, and F. Eto, The Rivermead Behavioral Memory Test (RMBT), Japanese Version, Chiba Test Center, Tokyo, Japan, 2002.
  48. B. A. Wilson, J. Cockburn, and A. Baddeley, The Rivermead Behavioral Memory Test (RMBT), Thames Valley Test Company, Bury St Edmunds, UK, 1986.
  49. K. Fujita, H. Maekawa, H. Dairoku, and K. Yamanaka, Wechsler Adult Intelligence Scale, Nihon Bunka Kagakusha, Tokyo, Japan, 3rd edition, 2006, (Japanese).
  50. D. Wechsler, Wechsler Adult Intelligence Scale—Third Edition (WAIS-III), The Psychological Corporation, San Antonio, Tex, USA, 1997.
  51. R. M. Reitan and D. Wolfson, The Halstead-Reitan Neuropsychological Test Battery, Neuropsychology Press, Tucson, Ariz, USA, 1985.
  52. R. K. Heaton, G. J. Chelune, J. K. Talley, G. G. Kay, and G. Curtiss, Wisconsin Card Sorting Test Manual: Revised and Expanded, Psychological Assessment Resources, Odessa, Tex, USA, 1993.
  53. T. Nemoto, C. Fujii, Y. Miura et al., “Reliability and validity of the Social Functioning Scale Japanese version (SFS-J),” Japanese Bulletin of Social Psychiatry, vol. 17, pp. 188–195, 2008 (Japanese). View at Google Scholar
  54. M. Birchwood, J. Smith, R. Cochrane, S. Wetton, S. Copestake, and M. Birchwood, “The social functioning scale. The development and validation of a new scale of social adjustment for use in family intervention programmes with schizophrenic patients,” The British Journal of Psychiatry, vol. 157, no. 6, pp. 853–859, 1990. View at Publisher · View at Google Scholar
  55. H. E. Nelson, “A modified card sorting test sensitive to frontal lobe defects,” Cortex, vol. 12, no. 4, pp. 313–324, 1976. View at Publisher · View at Google Scholar · View at Scopus
  56. J. Cohen, Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum Associates, Hillsdale, NJ, USA, 2nd edition, 1988.
  57. A. Aleman, R. Hijman, E. H. F. de Haan, and R. S. Kahn, “Memory impairment in schizophrenia: a meta-analysis,” The American Journal of Psychiatry, vol. 156, no. 9, pp. 1358–1366, 1999. View at Google Scholar · View at Scopus
  58. S. M. Eack, G. E. Hogarty, R. Y. Cho et al., “Neuroprotective effects of cognitive enhancement therapy against gray matter loss in early schizophrenia: results from a 2-year randomized controlled trial,” Archives of General Psychiatry, vol. 67, no. 7, pp. 674–682, 2010. View at Publisher · View at Google Scholar · View at Scopus
  59. S. Vinogradov, M. Fisher, C. Holland, W. Shelly, O. Wolkowitz, and S. H. Mellon, “Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?” Biological Psychiatry, vol. 66, no. 6, pp. 549–553, 2009. View at Publisher · View at Google Scholar · View at Scopus
  60. B. E. Wexler, M. Anderson, R. K. Fulbright, and J. C. Gore, “Preliminary evidence of improved verbal working memory performance and normalization of task-related frontal lobe activation in schizophrenia following cognitive exercises,” American Journal of Psychiatry, vol. 157, no. 10, pp. 1694–1697, 2000. View at Publisher · View at Google Scholar · View at Scopus