Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes

Table 1

List of components for fast dissolving buccal film (FDBF) formulations of CLH.

Sr.; No.	Ingredients; (% w/w)	Formulation Batches
		F1	F2	F3	F4	F5	F6	F7	F8	F9
1	Clonidine HCl	0.031	0.031	0.031	0.031	0.031	0.031	0.031	0.031	0.031
2	HPMC E15 (X1)	2	2	2	2.5	2.5	2.5	3	3	3
3	PEG-400 (X2)	2	4	6	2	4	6	2	4	6
4	Citric acid	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
5	Sodium lauryl sulphate	2	2	2	2	2	2	2	2	2
6	Xylitol	5	5	5	5	5	5	5	5	5
7	Flavor	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.2
8	Water (up to)	88.26	86.26	84.26	87.76	85.76	83.76	87.26	85.26	83.26

(X₁) and (X₂); Independent variables at low (2 and 2% w/w), medium (2.5 and 4% w/w), and high (3 and 6% w/w) levels, respectively.