Quality by Design (QbD) Assisted Fabrication of Fast Dissolving Buccal Film for Clonidine Hydrochloride: Exploring the Quality Attributes

Table 3

Characterization of fast dissolving buccal film formulations (FDBFs) of CLH.

Sr.; No.	Evaluation Parameters	Formulation Batches
		F1	F2	F3	F4	F5	F6	F7	F8	F9
1.	Thickness (mm)	0.113 ± 0.014	0.125 ± 0.012	0.132 ± 0.017	0.127 ± 0.015	0.153 ± 0.021	0.164 ± 0.015	0.142 ± 0.012	0.173 ± 0.014	0.198 ± 0.016
2.	Disintegration Time (s)	21 ± 2.3	25 ± 3	27 ± 3.6	21 ± 2.6	26 ± 3.3	28 ± 2.9	22 ± 2	26 ± 2.3	28 ± 3
3.	Folding Endurance	271 ± 4.65	288 ± 3.48	291 ± 3.91	279 ± 4.59	284 ± 4.35	295 ± 2.28	269 ± 5.72	274 ± 4.62	278 ± 3.23
4.	Tensile Strength (kg)	0.289 ± 0.009	0.312 ± 0.013	0.337 ± 0.007	0.293 ± 0.008	0.336 ± 0.015	0.352 ± 0.011	0.304 ± 0.019	0.357 ± 0.015	0.392 ± 0.023
5.	Moisture Content (%)	10.59 ± 0.92	11.25 ± 1.34	3.90 ± 0.67	11.02 ± 1.47	12.64 ± 1.26	4.94 ± 0.89	7.76 ± 1.09	5.87 ± 0.76	1.95 ± 0.59
6.	Surface pH	6.63 ± 0.05	6.51 ± 0.03	6.86 ± 0.07	6.62 ± 0.04	6.76 ± 0.06	6.83 ± 0.08	6.79 ± 0.07	6.54 ± 0.02	6.72 ± 0.05
7.	Drug Content (%)	90.21 ± 2.31	89.46 ± 3.60	92.20 ± 3.73	91.19 ± 2.81	95.96 ± 3.41	98.97 ± 3.27	91.24 ± 2.16	89.72 ± 3.83	88.65 ± 3.46
8.	In Vitro Drug Dissolution (%)	96.27 ± 1.37	97.09 ± 2.46	97.81 ± 1.79	95.98 ± 1.52	96.9 ± 1.84	99.7 ± 1.03	94.72 ± 2.65	96.02 ± 1.91	95.05 ± 1.64

Data is represented as mean ± SD, n = 3.