Evaluating pH in the Extracellular Tumor Microenvironment Using CEST MRI and Other Imaging Methods

Figure 3

Treatment of a mouse model of β-galactosidase-labeled MDA-MB-231 mammary carcinoma with 200 mM NaHCO₃ ad libitum for 60 days resulted in lower lung metastases as evidenced by (a) β-galactosidase-induced fluorescence staining of lung lesions and (b) the number of lesion pixels per animal. Reproduced with permission from [14].

(a)

(b)