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Volume 2010 (2010), Article ID 410975, 11 pages
http://dx.doi.org/10.1155/2010/410975
Research Article

Mutational and Bioinformatic Analysis of Haloarchaeal Lipobox-Containing Proteins

1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA
2Department of Membrane Biochemistry, Max-Planck-Institute of Biochemistry, Martinsried 82152, Germany
3Graduate Group in Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA
4Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA

Received 18 May 2010; Revised 4 July 2010; Accepted 12 July 2010

Academic Editor: Jerry Eichler

Copyright © 2010 Stefanie Storf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. J. M. Driessen and N. Nouwen, “Protein translocation across the bacterial cytoplasmic membrane,” Annual Review of Biochemistry, vol. 77, pp. 643–667, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Pohlschröder, E. Hartmann, N. J. Hand, K. Dilks, and A. Haddad, “Diversity and evolution of protein translocation,” Annual Review of Microbiology, vol. 59, pp. 91–111, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Natale, T. Brüser, and A. J. M. Driessen, “Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—distinct translocases and mechanisms,” Biochimica et Biophysica Acta, vol. 1778, no. 9, pp. 1735–1756, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Paetzel, A. Karla, N. C. J. Strynadka, and R. E. Dalbey, “Signal peptidases,” Chemical Reviews, vol. 102, no. 12, pp. 4549–4579, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. M. I. Hutchings, T. Palmer, D. J. Harrington, and I. C. Sutcliffe, “Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold 'em, knowing when to fold 'em,” Trends in Microbiology, vol. 17, no. 1, pp. 13–21, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Gan, S. D. Gupta, K. Sankaran, M. B. Schmid, and H. C. Wu, “Isolation and characterization of a temperature-sensitive mutant of Salmonella typhimurium defective in prolipoprotein modification,” The Journal of Biological Chemistry, vol. 268, no. 22, pp. 16544–16550, 1993. View at Google Scholar · View at Scopus
  7. K. Sankaran and H. C. Wu, “Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol,” The Journal of Biological Chemistry, vol. 269, no. 31, pp. 19701–19706, 1994. View at Google Scholar · View at Scopus
  8. S. D. Gupta and H. C. Wu, “Identification and subcellular localization of apolipoprotein N-acyltransferase in Escherichia coli,” FEMS Microbiology Letters, vol. 62, no. 1, pp. 37–41, 1991. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Tschumi, C. Nai, Y. Auchli et al., “Identification of apolipoprotein N-acyltransferase (Lnt) in mycobacteria,” The Journal of Biological Chemistry, vol. 284, no. 40, pp. 27146–27156, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Bolhuis, “Protein transport in the halophilic archaeon Halobacterium sp. NRC-1: a major role for the twin-arginine translocation pathway?” Microbiology, vol. 148, no. 11, pp. 3335–3346, 2002. View at Google Scholar · View at Scopus
  11. M. Falb, F. Pfeiffer, P. Palm et al., “Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis,” Genome Research, vol. 15, no. 10, pp. 1336–1343, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. I. Giménez, K. Dilks, and M. Pohlschröder, “Haloferax volcanii twin-arginine translocation substates include secreted soluble, C-terminally anchored and lipoproteins,” Molecular Microbiology, vol. 66, no. 6, pp. 1597–1606, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Mattar, B. Scharf, S. B. H. Kent, K. Rodewald, D. Oesterhelt, and M. Engelhard, “The primary structure of halocyanin, an archaeal blue copper protein, predicts a lipid anchor for membrane fixation,” The Journal of Biological Chemistry, vol. 269, no. 21, pp. 14939–14945, 1994. View at Google Scholar · View at Scopus
  14. K. F. Chater, S. Biró, K. J. Lee, T. Palmer, and H. Schrempf, “The complex extracellular biology of Streptomyces,” FEMS Microbiology Reviews, vol. 34, no. 2, pp. 171–198, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. D. A. Widdick, K. Dilks, G. Chandra et al., “The twin-arginine translocation pathway is a major route of protein export in Streptomyces coelicolor,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 47, pp. 17927–17932, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Dyall-Smith, Halohandbook: Protocols for Haloarchaeal Genetics, 2008, http://www.haloarchaea.com/resources/halohandbook/Halohandbook_2008_v7.pdf.
  17. G. Bitan-Banin, R. Ortenberg, and M. Mevarech, “Development of a gene knockout system for the halophilic archaeon Haloferax volcanii by use of the pyrE gene,” Journal of Bacteriology, vol. 185, no. 3, pp. 772–778, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Holmes, F. Pfeifer, and M. Dyall-Smith, “Improved shuttle vectors for Haloferax volcanii including a dual-resistance plasmid,” Gene, vol. 146, no. 1, pp. 117–121, 1994. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Large, C. Stamme, C. Lange et al., “Characterization of a tightly controlled promoter of the halophilic archaeon Haloferax volcanii and its use in the analysis of the essential cct1 gene,” Molecular Microbiology, vol. 66, no. 5, pp. 1092–1106, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. L. B. Blyn, B. A. Braaten, and D. A. Low, “Regulation of pap pilin phase variation by a mechanism involving differential Dam methylation states,” EMBO Journal, vol. 9, no. 12, pp. 4045–4054, 1990. View at Google Scholar · View at Scopus
  21. T. Allers, H.-P. Ngo, M. Mevarech, and R. G. Lloyd, “Development of additional selectable markers for the halophilic Archaeon Haloferax volcanii based on the leuB and trpA genes,” Applied and Environmental Microbiology, vol. 70, no. 2, pp. 943–953, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Dilks, M. I. Giménez, and M. Pohlschröder, “Genetic and biochemical analysis of the twin-arginine translocation pathway in halophilic archaea,” Journal of Bacteriology, vol. 187, no. 23, pp. 8104–8113, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Hulo, A. Bairoch, V. Bulliard et al., “The 20 years of PROSITE,” Nucleic Acids Research, vol. 36, no. 1, pp. D245–D249, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. A. S. Juncker, H. Willenbrock, G. Von Heijne, S. Brunak, H. Nielsen, and A. Krogh, “Prediction of lipoprotein signal peptides in Gram-negative bacteria,” Protein Science, vol. 12, no. 8, pp. 1652–1662, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. P. G. Bagos, K. D. Tsirigos, T. D. Liakopoulos, and S. J. Hamodrakas, “Prediction of lipoprotein signal peptides in Gram-positive bacteria with a Hidden Markov Model,” Journal of Proteome Research, vol. 7, no. 12, pp. 5082–5093, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. R. W. Rose, T. Brüser, J. C. Kissinger, and M. Pohlschröder, “Adaptation of protein secretion to extremely high-salt conditions by extensive use of the twin-arginine translocation pathway,” Molecular Microbiology, vol. 45, no. 4, pp. 943–950, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Käll, A. Krogh, and E. L. L. Sonnhammer, “A combined transmembrane topology and signal peptide prediction method,” Journal of Molecular Biology, vol. 338, no. 5, pp. 1027–1036, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. B. C. Berks, T. Palmer, and F. Sargent, “Protein targeting by the bacterial twin-arginine translocation (Tat) pathway,” Current Opinion in Microbiology, vol. 8, no. 2, pp. 174–181, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Dilks, R. W. Rose, E. Hartmann, and M. Pohlschröder, “Prokaryotic utilization of the twin-arginine translocation pathway: a genomic survey,” Journal of Bacteriology, vol. 185, no. 4, pp. 1478–1483, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. D. J. Näther and R. Rachel, “The outer membrane of the hyperthermophilic archaeon Ignicoccus: dynamics, ultrastructure and composition,” Biochemical Society Transactions, vol. 32, no. 2, pp. 199–203, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Hayashi, S.-Y. Chang, and S. Chang, “Modification and processing of internalized signal sequences of prolipoprotein in Escherichia coli and in Bacillus subtilis,” The Journal of Biological Chemistry, vol. 260, no. 9, pp. 5753–5759, 1985. View at Google Scholar · View at Scopus
  32. W. W. Navarre, S. Daefler, and O. Schneewind, “Cell wall sorting of lipoproteins in Staphylococcus aureus,” Journal of Bacteriology, vol. 178, no. 2, pp. 441–446, 1996. View at Google Scholar · View at Scopus
  33. D. Cavard, D. Baty, and S. P. Howard, “Lipoprotein nature of the colicin A lysis protein: effect of amino acid substitutions at the site of modification and processing,” Journal of Bacteriology, vol. 169, no. 5, pp. 2187–2194, 1987. View at Google Scholar · View at Scopus