Synthetic Archaeosome Vaccines Containing Triglycosylarchaeols Can Provide Additive and Long-Lasting Immune Responses That Are Enhanced by Archaetidylserine

Figure 6

Elispot assay showing a relationship between mol% AS in a triglycosyl-A/PGP archaeosome and CD8 adjuvant activity. Mannotriosyl-A and gentiotriosyl-A were always 22.5 mol% each. AS was varied as shown at 0, 10, 20, and 30 mol%, with PGP making the remainder of each composition. For comparison, archaeosomes containing 5 mol% AE and M. smithii total polar lipid archaeosomes are included.