Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins
Figure 4
Insights into XPD from archaeal structures. Structures of XPDs from S. acidocaldarius (PDB code 3CRV), S. tokodaii (PDB code 2VL7), and T. acidophilum XPD with (PDB code 4A15) and without DNA (PDB code 2VSF) reveal Arch, Fe-S, HD1, and HD2 domains forming a seat-shaped molecule. Notably, despite similar architecture, cleft pore size between Arch and Fe-S domains varies, suggesting flexibility in this region. DNA orientation is shown for T. acidophilum XPD, and a calcium ion is shown as a pink sphere.
