Catalytic Intermediate Crystal Structures of Cysteine Desulfurase from the Archaeon Thermococcus onnurineus NA1

Figure 1

Structural sequence alignment of ToCDS with EcCDSs. ToCDS is CDS from Thermococcus onnurineus NA1; EcISCS, EcSUFS, and EcCSDA are IscS, SufS, and CsdA from E. coli. Conserved catalytic Cys and Lys residues are labelled with an asterisk. The class I sequence insertion is shown in an orange rectangle and the class II sequence insertion in a pink rectangle. The helix α3 and α10 of ToCDS and the corresponding helices of EcCDSs are shown in blue rectangles.