(a)
(b)
Figure 7: Diversity and phylogeny of metabolic models. (a) The uniqueness of the reactions in each of the metabolic models. Here, we define uniqueness to be the fraction of 221 archaea that do not have the reaction currently present in the respective model; higher uniqueness means fewer of the organisms contain the genes coding enzymes that are annotated by the GPRs of the specified models. The presence of the genes is computed using ITEP as discussed in Figure 5. (b) A phylogenetic tree computed based on similarity to the M. acetivorans model iST807. This tree is based on the ITEP results discussed in Figure 5.