Inorganic Polyphosphate, Exopolyphosphatase, and Pho84-Like Transporters May Be Involved in Copper Resistance in Metallosphaera sedula DSM 5348T

<div>Catalytic residues of the possible active site of PPXMsed. (a) Protein sequence alignment of the residues in the potential active site of M. sedula, S. solfataricus, A. aeolicus, and E. coli PPXs. The residues that have been proven essential for catalysis in PPXEco are highlighted in bold [<a href="/journals/archaea/2018/5251061/#B32">32</a>, <a href="/journals/archaea/2018/5251061/#B33">33</a>] (asterisk indicates fully conserved residue, colon indicates strongly similar properties, and period indicates weakly similar properties). (b) Activity of PPXMsed and the E111A and E113A mutants. (c) Cartoon representation of the possible active site of PPXMsed. Amino acids in the metal binding site are shown in pink, the mutated residues are shown in cyan, and residues near E111 are shown in yellow.</div>

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Figure 3: Inorganic Polyphosphate, Exopolyphosphatase, and Pho84-Like Transporters May Be Involved in Copper Resistance in Metallosphaera sedula DSM 5348T

Figure 3 | Inorganic Polyphosphate, Exopolyphosphatase, and Pho84-Like Transporters May Be Involved in Copper Resistance in Metallosphaera sedula DSM 5348T 