Comparative Genomic Analysis of Members of the Genera Methanosphaera and Methanobrevibacter Reveals Distinct Clades with Specific Potential Metabolic Functions

Figure 3

Pan/core genome analysis of three different Methanosphaera species. Venn diagram showing the numbers of orthologous genes (OGs) in the core, dispensable, and specific genome of compared strains. Ortholog detection was done with the Proteinortho software (blastp) with a similarity cut-off of 50% and an value of 1e − 10. The total numbers of genes and paralogs are depicted under the corresponding species name. Open-reading frames that were classified as pseudo genes were not included in this analysis. See also Table S3 for details on shared genes.