Molecular Regulation of Striatal Development: A Review

Figure 4

The Shh pathway for target gene expression: (a) repressed pathway—when SHH cannot bind Ptc, ptc represses gene expression by being bound to Smo. Smo cannot then activate the Gli complex meaning the target gene is repressed. (b) Induction pathway—when SHH binds ptc, smo is released which allows the GliA to bind the DNA and activate gene expression. Abbreviations: SHH: sonic hedgehog, Ptc: patched, Smo: smoothened, GliA: Gli Activator.