Role of Erythropoietin and Other Growth Factors in Ex Vivo Erythropoiesis

Table 1

Various growth factors and their functional implications in erythropoiesis.

Sr. Number	Growth factor	Protein size	Target cells	Target receptor	Functions
1	Erythropoietin	21.0 kDa	CFU-E	EPOR	Differentiation and proliferation of erythroid
2	Granulocyte macrophage colony-stimulating factor	14.6 kDa	HPP-CFC, CFU-GEMM, CFU-GM, CFU-Eo, CFU-Baso, CFU-Mk, BFU-E, CFU-M, CFU-G, dendritic cells	CD116	White blood cell growth factor
3	Interleukin-3	17.2 kDa	CFU-GEMM, HPP-CFC, CFU-GM, CFU-Eo, CFU-Baso, BFU-E, CFU-Mk	CD123/IL3RA, CD131/IL3RB	Differentiation and proliferation of myeloid progenitor cells
4	Interleukin-6	20.9 kDa	HPP-CFC, CFU-GM, BFU-E	CD126/IL6RA, CD130/IR6RB	Differentiation
5	Stem cell factor	42.0 kDa	HPP-CFC, CFU-GEMM, CFU-GM, CFU-Baso, BFU-E	CD117	Regulates HSCs in the bone marrow
6	Granulocyte colony-stimulating factor	18.8 kDa	HPP-CFC, CFU-GEMM, CFU-GM, CFU-G	CD114	Inducer of HSCs mobilization from the bone marrow into the bloodstream
7	Insulin growth factor	7.6 kDa	Endothelial progenitor cells	IGF1R	Inhibits apoptosis in hematopoietic progenitor cells