Table 1: Pharmacology of common local anesthetics. Potency is relative. Potency: toxicity ratio is a useful evaluation to consider, articaine has the best ratio making it clinically efficacious as well as safe. %PB = protein binding.

PotencyPot : ToxLWPCOnsetpKa (min)%PB

Bupivacaine8227.5Slow8.116295.6
Articaine33.317Fast7.82094
Lignocaine222.9Fast7.99664.3
Mepivacaine22.219.3Fast7.811478
Prilocaine22.70.9Fast7.79355
Ropivacaine42.252.9Mod8.19694