Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model
Electrophysiological recording of chronic constricted median nerves at pre- and postelectrical stimulation, (pre-ES and post-ES) stages. Data were collected and transformed into frequency histogram for control (a), presaline (b), pre-1% lido (c), and pre-5% lido (d) groups. Original recordings presented above the histogram, respectively. Note that the rates of discharges were significantly reduced with increasing concentrations of lidocaine pre-treatment.
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