Pre-Emptive Treatment of Lidocaine Attenuates Neuropathic Pain and Reduces Pain-Related Biochemical Markers in the Rat Cuneate Nucleus in Median Nerve Chronic Constriction Injury Model
Histograms showing morphometric assessments used to quantify intensity of NPY-LI fibers in the middle CN at four weeks after chronic constriction injury without (CCI) or with electrical stimulation (CCI + ES). It is notable that the intensities of NPY-LI fibers in the CN were significantly lower in rats with electrical stimulation than those without stimulation in the presaline and pre-1% lidocaine groups (# compared with unstimulated side in respective group). The intensity of NPY-LI fibers in the CN was also reduced by lidocaine pretreatment in a dose-dependent manner (☆, * compared with the stimulated and unstimulated side of the presaline group, resp.).
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