Prediction of Optimal Reversal Dose of Sugammadex after Rocuronium Administration in Adult Surgical Patients

Figure 1

Patient flow through the study. Groups A and B received 1 mg/kg and 0.5 mg/kg of sugammadex (Sug), respectively, as a first dose when the second twitch (T2) reappeared in train-of-four stimulation (TOF), and Groups C and D received 1 mg/kg and 0.5 mg/kg of Sug, respectively, as the first dose at posttetanic counts 1–3 (PTC 1–3). Five minutes after the first dose, an additional 1 mg/kg of Sug was administered and changes in first twitch height of TOF (T1 height) and train-of-four ratio (TOFR) were observed. Patients were divided into a recovered group and a partly recovered group, based on percentage changes in T1 height after additional dosing. T1 height and TOFR during the 5 min after first dose were then compared.