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Anesthesiology Research and Practice
Volume 2014 (2014), Article ID 848051, 5 pages
http://dx.doi.org/10.1155/2014/848051
Clinical Study

Prediction of Optimal Reversal Dose of Sugammadex after Rocuronium Administration in Adult Surgical Patients

Department of Anesthesiology and Critical Care, Asahikawa Medical University, 2-1-1-1 Midorigaoka-higashi, Asahikawa, Hokkaido 078-8510, Japan

Received 28 September 2013; Revised 6 January 2014; Accepted 6 January 2014; Published 11 February 2014

Academic Editor: D. John Doyle

Copyright © 2014 Shigeaki Otomo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Suy, K. Morias, G. Cammu et al., “Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex, a selective relaxant binding agent,” Anesthesiology, vol. 106, no. 2, pp. 283–288, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. S. B. Groudine, R. Soto, C. Lien, D. Drover, and K. Roberts, “A randomized, dose-finding, phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block,” Anesthesia and Analgesia, vol. 104, no. 3, pp. 555–562, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. D. J. Eleveld, K. Kuizenga, J. H. Proost, and J. M. K. H. Wierda, “A temporary decrease in twitch response during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadex,” Anesthesia and Analgesia, vol. 104, no. 3, pp. 582–584, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Pongrácz, S. Szatmári, R. Nemes et al., “Reversal of neuromuscular blockade with sugammadex at the reappearance of four twitches train-of-four stimulation,” Anesthesiology, vol. 119, pp. 36–42, 2013. View at Google Scholar
  5. I. F. Sorgenfrei, K. Norrild, P. B. Larsen et al., “Reversal of rocuronium-induced neuromuscular block by the selective relaxant binding agent sugammadex: a dose-finding and safety study,” Anesthesiology, vol. 104, no. 4, pp. 667–674, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Duvaldestin, K. Kuizenga, V. Saldien et al., “A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia,” Anesthesia and Analgesia, vol. 110, no. 1, pp. 74–82, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. L. I. Eriksson, M. Sato, and J. W. Severinghaus, “Effect of a vecuronium-induced partial neuromuscular block on hypoxic ventilatory response,” Anesthesiology, vol. 78, no. 4, pp. 693–699, 1993. View at Google Scholar · View at Scopus
  8. T. Suzuki, “A train-of-four ratio of 0.9 may not certify adequate recovery after sugammadex,” Acta Anaesthesiologica Scandinavica, vol. 55, no. 3, pp. 368–369, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Mosing, U. Auer, D. Bardell, R. S. Jones, and J. M. Hunter, “Reversal of profound rocuronium block monitored in three muscle groups with sugammadex in ponies,” British Journal of Anaesthesia, vol. 105, no. 4, pp. 480–486, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. S. Arbous, A. E. E. Meursing, J. W. van Kleef et al., “Impact of anesthesia management characteristics on severe morbidity and mortality,” Anesthesiology, vol. 102, no. 2, pp. 257–268, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. P. A. M. Peeters, M. W. van den Heuvel, E. van Heumen et al., “Safety, tolerability and pharmacokinetics of sugammadex using single high doses (Up to 96 mg/kg) in healthy adult subjects: a randomized, double-blind, crossover, placebo-controlled, single-centre study,” Clinical Drug Investigation, vol. 30, no. 12, pp. 867–874, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Cammu, P.-J. De Kam, K. De Graeve et al., “Repeat dosing of rocuronium 1.2 mg kg−1 after reversal of neuromuscular block by sugammadex 4.0 mg kg−1 in anaesthetized healthy volunteers: a modelling-based pilot study,” British Journal of Anaesthesia, vol. 105, no. 4, pp. 487–492, 2010. View at Publisher · View at Google Scholar · View at Scopus