Perioperative Elevation in Cell-Free DNA Levels in Patients Undergoing Cardiac Surgery: Possible Contribution of Neutrophil Extracellular Traps to Perioperative Renal Dysfunction

Figure 6

Association between serum double-strand DNA (dsDNA) concentration and serum creatinine concentration. (a) Relationship between serum dsDNA concentration and serum creatinine concentration. Spearman’s tests were performed at baseline, immediately after surgery (PostOp), and the day after surgery (POD-1). X marks, baseline; open circles, PostOp; open squares, POD-1. (b) Relationship between the change in serum creatinine concentration from baseline to POD-1 () and dsDNA concentration on POD-1. X marks, off-pump surgery; open squares, on-pump surgery. (c) Serum dsDNA concentration in patients with or without acute kidney injury (AKI). Patients with AKI showed a significantly higher value of dsDNA on POD-1 than those without AKI (non-AKI). : correlation coefficient calculated from Spearman’s tests.

(a)

(b)

(c)