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Anesthesiology Research and Practice
Volume 2017 (2017), Article ID 2753962, 7 pages
https://doi.org/10.1155/2017/2753962
Clinical Study

Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery

1Intensive Care Unit, Medical School of Larissa, University of Thessaly, Volos, Greece
2Department of Anesthesiology, Medical School of Larissa, University of Thessaly, Volos, Greece
3Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA
4Department of Cardiothoracic Surgery, Medical School of Larissa, University of Thessaly, Volos, Greece

Correspondence should be addressed to Menelaos Karanikolas; moc.oohay@soalenemk

Received 13 December 2016; Revised 20 March 2017; Accepted 5 April 2017; Published 30 April 2017

Academic Editor: Ronald G. Pearl

Copyright © 2017 Aik Bouzia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Pain after cardiac surgery affects long-term patient wellness. This study investigated the effect of preoperative pregabalin on acute and chronic pain after elective cardiac surgery with median sternotomy. Methods. Prospective double blind study. 93 cardiac surgery patients were randomly assigned into three groups: Group 1 received placebo, Group 2 received oral pregabalin 75 mg, and Group 3 received oral pregabalin 150 mg. Data were collected 8 hours, 24 hours, and 3 months postoperatively. Results. Patients receiving pregabalin required fewer morphine boluses (10 in controls versus 6 in Group 1 versus 4 in Group 2, ) and had lower pain scores at 8 hours (4 versus 3 versus 3, ) and 3 months (3 versus 2 versus 2, ) and lower morphine consumption at 8 hours (14 versus 13 versus 12 mg, ) and 24 hours (19.5 versus 16 versus 15 mg, ). Percentage of patients with sleep disturbances or requiring analgesics was lower in the pregabalin group and even lower with higher pregabalin dose (16/31 versus 5/31 versus 3/31, , and 26/31 versus 16/31 versus 10/31, , resp.) 3 months after surgery. Conclusion. Preoperative oral pregabalin 75 or 150 mg reduces postoperative morphine requirements and acute and chronic pain after cardiac surgery.