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Anesthesiology Research and Practice
Volume 2017, Article ID 6182350, 7 pages
Research Article

Organs Blood Flow during Elevation of Body Temperature in Sevoflurane Anesthetized Rats

1Department of Anesthesiology and Reanimatology, Faculty of Medical Sciences, Fukui University, Fukui, Japan
2Department of Anesthesiology, Gifu Prefectural Gero Hot Spring Hospital, Gifu, Japan

Correspondence should be addressed to Koichi Shimo;

Received 19 February 2017; Revised 26 April 2017; Accepted 14 May 2017; Published 4 June 2017

Academic Editor: Ronald G. Pearl

Copyright © 2017 Koichi Shimo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study is to investigate how elevation of body temperature changes organs blood flow during sevoflurane anesthesia. We conducted in vivo research on 14 male Wistar rats to monitor pulse rate and arterial blood pressure and measure hepatic, small intestinal, renal, and descending aortic blood flow using a laser Doppler blood flowmeter. We assessed the changes in organ blood flow, pulse rate, and arterial blood pressure during elevation of the rats’ body temperatures up to 41.5°C under anesthesia with 2.0% or 3.0% sevoflurane. We concluded that elevation of body temperature up to 39.5°C does not change hepatic, small intestinal, and renal blood flow during 2.0 and 3.0% sevoflurane anesthesia.