Anesthesiology Research and Practice

Review Article

Intravenous Magnesium Sulphate for Analgesia after Caesarean Section: A Systematic Review

Table 3

Intervention regimens per trial.


	Patient type	Timing of intervention	Dosing protocol

Elgebaly et al., 2011	Severe preeclampsia (SBP ≥ 160 mmHg or DBP ≥ 100 mmHg or proteinuria ≥ 100 mg/dL)	(i) Bolus 30 minutes before spinal	(i) Bolus: 6 g magnesium sulphate in 100 mL NS over 30 minutes
		(ii) Infusion commenced following bolus	(ii) Infusion: 2 g/hr magnesium sulphate for 24 hr
			(iii) Controls 1 and 2: 160 mL NS over 30 minutes and then 60 mL NS infusion for 24 hr

Elrahman and Youssry, 2017	ASA I and II Elective Excluded preeclampsia patient	(i) Bolus 30 minutes before spinal	(i) Bolus: magnesium sulphate 50 mg/kg in 100 mL NS over 20 minutes

Helmy et al., 2015	ASA I and II Elective No preeclampsia patients	(i) 10 minutes before induction	(i) Bolus: magnesium sulphate 30 mg/kg in 20 mL NS over 10 minutes
			(ii) Control 1: ketamine 0.3 mg/kg in 20 mL NS over 10 minutes
			(iii) Control 2: 20 mL NS over 10 minutes

Maulik et al., 2015	Severe preeclampsia ASA < III BMI 18.5–35	(i) 30 minutes before surgery	(i) Bolus: magnesium sulphate 40 mg/kg in 100 mL NS over 15 minutes
		(ii) Infusion commenced following bolus	(ii) Infusion: magnesium sulphate 10 mg/kg/hr for 24 hr
			(iii) Control: NS of same volume and rate for both bolus and infusion

Mireskandari et al., 2015	ASA I and II Hypertension excluded	(i) Before induction	(i) Bolus: magnesium sulphate 50 mg/kg in 500 mL NS over 15 minutes
			(ii) Control: 500 mL NS over 15 minutes

Paech et al., 2006	Elective No preeclampsia patients	(i) One hour before surgery	Group 1
			(i) Bolus: magnesium sulphate 50 mg/kg
			(ii) Infusion: magnesium sulphate 2 g/hr for 24 hr
		(ii) Infusion commenced following bolus	Group 2
			(i) Bolus: magnesium sulphate 25 mg/kg
			(ii) Infusion: magnesium sulphate 1 g/hr for 24 hr
			(iii) Control: NS at same volume and rate

Rezae et al., 2014	Elective	(i) 30 minutes before induction	(i) Bolus: magnesium sulphate 50 mg/kg in 100 mL NS over 10 minutes
			(ii) Control: NS at same volume and rate

SBP = systolic blood pressure, DBP = diastolic blood pressure, NS = normal saline, hr = hours, ASA = American Society of Anesthesiologists Physical Status Classification System, BMI = body mass index.