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AIDS Research and Treatment
Volume 2010, Article ID 142076, 6 pages
http://dx.doi.org/10.1155/2010/142076
Research Article

Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia

1Service de Médecine Interne, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, France
2Unité d'Epidémiologie des maladies émergentes, Institut Pasteur, 75015 Paris, France
3Service de Maladies Infectieuses, Hôpital Calmette, 12100 Phnom-Penh, Cambodia
4Service de Pharmacologie, Centre Hospitalier Universitaire de Bicêtre, AP-HP, 94270 Le Kremlin Bicêtre, France
5Laboratoire VIH/Hépatites, Institut Pasteur, 12100 Phnom-Penh, Cambodia

Received 18 August 2009; Accepted 24 November 2009

Academic Editor: Patrice K. Nicholas

Copyright © 2010 Olivier Segeral et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. J. Palella Jr., K. M. Delaney, A. C. Moorman et al., “Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators,” The New England Journal of Medicine, vol. 338, pp. 853–860, 1998. View at Google Scholar
  2. “Towards universal access: scaling up priority HIV/AIDS interventions in the health sector,” Progress Report, WHO, UNAIDS, UNICEF, Geneva, Switzerland, 2008.
  3. C. Laurent, N. Diakhate, N. F. Gueye et al., “The Senegalese government's highly active antiretroviral therapy initiative: an 18-month follow-up study,” AIDS, vol. 16, no. 10, pp. 1363–1370, 2002. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Galvao, “Access to antiretroviral drugs in Brazil,” The Lancet, vol. 360, no. 9348, pp. 1862–1865, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Phanuphak, “Antiretroviral treatment in resource-poor settings: what can we learn from the existing programmes in Thailand?” AIDS, vol. 18, supplement 3, pp. S33–S38, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Laurent, C. Kouanfack, P. S. Koulla-Shiro et al., “Effectiveness and safety of a generic fixed-dose combination of nevirapine, stavudine, and lamivudine in HIV-1-infected adults in Cameroon: open-label multicentre trial,” The Lancet, vol. 364, no. 9428, pp. 29–34, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Ferradini, A. Jeannin, L. Pinoges et al., “Scaling up of highly active antiretroviral therapy in a rural district of Malawi: an effectiveness assessment,” The Lancet, vol. 367, no. 9519, pp. 1335–1342, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Katzenstein, M. Laga, and J.-P. Moatti, “The evaluation of the HIV/AIDS drug access initiatives in Cote d'Ivoire, Senegal and Uganda: how access to antiretroviral treatment can become feasible in Africa,” AIDS, vol. 17, supplement 3, pp. S1–S4, 2003. View at Google Scholar · View at Scopus
  9. A. Calmy, L. Pinoges, E. Szumilin, R. Zachariah, N. Ford, and L. Ferradini, “Generic fixed-dose combination antiretroviral treatment in resource-poor settings: multicentric observational cohort,” AIDS, vol. 20, no. 8, pp. 1163–1169, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. L. C. Ivers, D. Kendrick, and K. Doucette, “Efficacy of antiretroviral therapy programs in resource-poor settings: a meta-analysis of the published literature,” Clinical Infectious Diseases, vol. 41, no. 2, pp. 217–224, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Akileswaran, M. N. Lurie, T. P. Flanigan, and K. H. Mayer, “Lessons learned from use of highly active antiretroviral therapy in Africa,” Clinical Infectious Diseases, vol. 41, no. 3, pp. 376–385, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. J.-P. Moatti, B. Spire, and M. Kazatchkine, “Drug resistance and adherence to HIV/AIDS antiretroviral treatment: against a double standard between the north and the south,” AIDS, vol. 18, supplement 3, pp. S55–S61, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Galárraga, M. E. O'Brien, J. P. Gutiérrez et al., “Forecast of demand for antiretroviral drugs in low and middle-income countries: 2007-2008,” AIDS, vol. 21, supplement 4, pp. S97–S103, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. P. R. Harrigan, R. S. Hogg, W. W. Y. Dong et al., “Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy,” Journal of Infectious Diseases, vol. 191, no. 3, pp. 339–347, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. M. P. Carrieri, F. Raffi, C. Lewden et al., “Impact of early versus late adherence to highly active antiretroviral therapy on immuno-virological response: a 3-year follow-up study,” Antiviral Therapy, vol. 8, no. 6, pp. 585–594, 2003. View at Google Scholar · View at Scopus
  16. A. K. Sethi, D. D. Celentano, S. J. Gange, R. D. Moore, and J. E. Gallant, “Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance,” Clinical Infectious Diseases, vol. 37, no. 8, pp. 1112–1118, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. A. D. Harries, E. J. Schouten, and E. Libamba, “Scaling up antiretroviral treatment in resource-poor settings,” The Lancet, vol. 367, no. 9525, pp. 1870–1872, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Goujard, N. Bernard, N. Sohier et al., “Impact of a patient education program on adherence to HIV medication: a randomized clinical trial,” Journal of Acquired Immune Deficiency Syndromes, vol. 34, no. 2, pp. 191–194, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Marchand, H. Himmich, A. Maaroufi, N. Sohier, J. F. Chambon, and R. Gagnayre, “Implementation and assessment of an HIV treatment training program (2000-2001) for patients in Casablanca (Morocco),” Sante, vol. 15, no. 2, pp. 73–80, 2005. View at Google Scholar · View at Scopus
  20. J. Iguenane, C. Marchand, D. Bodelot et al., “Implementation of therapeutic education programmes for patients living with HIV in four low-income countries: an evaluative approach,” Sante Publique, vol. 19, no. 4, pp. 323–333, 2007. View at Google Scholar · View at Scopus
  21. M. I. B. Nemes, H. B. Carvalho, and M. F. M. Souza, “Antiretroviral therapy adherence in Brazil,” AIDS, vol. 18, supplement 3, pp. S15–S20, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. T. R. Glass, S. De Geest, R. Weber et al., “Correlates of self-reported nonadherence to antiretroviral therapy in HIV-infected patients: the Swiss HIV Cohort Study,” Journal of Acquired Immune Deficiency Syndromes, vol. 41, no. 3, pp. 385–392, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. T. P. Giordano, D. Guzman, R. Clark, E. D. Charlebois, and D. R. Bangsberg, “Measuring adherence to antiretroviral therapy in a diverse population using a visual analogue scale,” HIV Clinical Trials, vol. 5, no. 2, pp. 74–79, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. K. R. Amico, W. A. Fisher, D. H. Cornman et al., “Visual analog scale of ARV adherence: association with 3-day self-report and adherence barriers,” Journal of Acquired Immune Deficiency Syndromes, vol. 42, pp. 455–459, 2006. View at Google Scholar
  25. S. Duran, G. Peytavin, P. Carrieri et al., “The detection of non-adherence by self-administered questionnaires can be optimized by protease inhibitor plasma concentration determination,” AIDS, vol. 17, no. 7, pp. 1096–1099, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. C. S. Alexander, J. J. Asselin, L. S. L. Ting et al., “Antiretroviral concentrations in untimed plasma samples predict therapy outcome in a population with advanced disease,” Journal of Infectious Diseases, vol. 188, no. 4, pp. 541–548, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Duong, L. Piroth, G. Peytavin et al., “Value of patient self-report and plasma human immunodeficiency virus protease inhibitor level as markers of adherence to antiretroviral therapy: relationship to virologic response,” Clinical Infectious Diseases, vol. 33, no. 3, pp. 386–392, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. J. H. Arnsten, P. A. Demas, H. Farzadegan et al., “Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: comparison of self-report and electronic monitoring,” Clinical Infectious Diseases, vol. 33, no. 8, pp. 1417–1423, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. P. W. H. Hugen, N. Langebeek, D. M. Burger et al., “Assessment of adherence to HIV protease inhibitors: comparison and combination of various methods, including MEMS (electronic monitoring), patient and nurse report, and therapeutic drug monitoring,” Journal of Acquired Immune Deficiency Syndromes, vol. 30, no. 3, pp. 324–334, 2002. View at Google Scholar · View at Scopus
  30. F. Romanelli, K. Empey, and C. Pomeroy, “Macrocytosis as an indicator of medication (zidovudine) adherence in patients with HIV infection,” AIDS Patient Care and STDs, vol. 16, no. 9, pp. 405–411, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Rouet, D. K. Ekouevi, M.-L. Chaix et al., “Transfer and evaluation of an automated, low-cost real-time reverse transcription-PCR test for diagnosis and monitoring of human immunodeficiency virus type 1 infection in a West African resource-limited setting,” Journal of Clinical Microbiology, vol. 43, no. 6, pp. 2709–2717, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Ferradini, D. Laureillard, N. Prak et al., “Positive outcomes of HAART at 24 months in HIV-infected patients in Cambodia,” AIDS, vol. 21, no. 17, pp. 2293–2301, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Spire, P. Carrieri, P. Sopha et al., “Adherence to antiretroviral therapy in patients enrolled in a comprehensive care program in Cambodia: a 24-month follow-up assessment,” Antiviral Therapy, vol. 13, no. 5, pp. 697–703, 2008. View at Google Scholar · View at Scopus
  34. J. H. Oyugi, J. Byakika-Tusiime, K. Ragland et al., “Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, Uganda,” AIDS, vol. 21, no. 8, pp. 965–971, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Mee, K. L. Fielding, S. Charalambous, G. J. Churchyard, and A. D. Grant, “Evaluation of the WHO criteria for antiretroviral treatment failure among adults in South Africa,” AIDS, vol. 22, no. 15, pp. 1971–1977, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. A. N. Phillips, D. Pillay, A. H. Miners, D. E. Bennett, C. F. Gilks, and J. D. Lundgren, “Outcomes from monitoring of patients on antiretroviral therapy in resource-limited settings with viral load, CD4 cell count, or clinical observation alone: a computer simulation model,” The Lancet, vol. 371, no. 9622, pp. 1443–1451, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. H. O. Ramadhani, N. M. Thielman, K. Z. Landman et al., “Predictors of incomplete adherence, virologic failure, and antiviral drug resistance among HIV-infected adults receiving antiretroviral therapy in Tanzania,” Clinical Infectious Diseases, vol. 45, no. 11, pp. 1492–1498, 2007. View at Publisher · View at Google Scholar · View at Scopus