Research Article
Simplified Assessment of Antiretroviral Adherence and Prediction of Virological Efficacy in HIV-Infected Patients in Cambodia
Table 3
Association between the four measures of adherence and virological failure in the previously HAART-naïve population.
| | | Virological failure: (%) | OR [95% CI] | |
| Self-report questionnaire (all three items)* | | | | |
| 100% adherent | 134 | 22 (16.4) | 1 | | At least one missed HAART dose | 22 | 8 (36.4) | 2.91 [1.09–7.76] | .034 |
| Visual analog scale* | | | | |
| 10 | 110 | 20 (18.1) | 1 | | 9 | 39 | 8 (20.5) | 1.16 [0.46–2.90] | .78 | <9 | 7 | 2 (28.6) | 1.8 [0.32–9.95] | |
| Antiretroviral drug concentrations (ng/mL) | | | | |
| 1000 for EFV or 3000 for NVP | 149 | 24 (16.1) | 1 | | <1000 for EFV or <3000 for NVP | 9 | 6 (66.7) | 10.42 [2.43–44.54] | .002 |
| Macrocytosis (MCV 100 fL)** | | | | |
| Yes | 141 | 23 (16.3) | 1 | | No | 14 | 7 (50) | 5.13 [1.64–16.02] | .007 |
| Self-report questionnaire and macrocytosis | | | | |
| 100% adherent | 121 | 18 (14.9) | 1 | | At least one mistake | 32 | 12 (37.5) | 3.43 [1.43–8.22] | .006 |
| Self-report questionnaire and drug assays | | | | |
| 100% adherent | 129 | 20 (15.5) | 1 | | At least one mistake | 27 | 10 (37) | 3.20 [1.28–8] | .015 |
|
|
OR: odds ratio; CI: confidence interval, *Available for 156 patients, **Available for 155 patients.
|