30–49 mL/min = 150 mg once a day orally 15–29 mL/min = 100 mg once a day orally 5–14 mL/min = 50 mg once a day orally <5 mL/min = 25 mg once a day orally
Stavudine
30 mg twice a day orally
26–50 mL/min = 15 mg twice a day orally <26 mL/min = 15 mg once a day orally
Didanosine
>60 kg: 200 mg twice a day orally <60 kg, 125 mg twice a day orally
30–59 mL/min = 200 mg once a day orally 10–29 mL/min = 150 mg once a day orally <10 mL/min = 100 mg once a day orally 30–59 mL/min = 150 mg once a day orally 10–29 mL/min = 100 mg once a day orally <10 mL/min = 75 mg once a day orally
Tenofovir
300 mg once a day orally
30–49 mL/min = 300 mg every second day 10–29 mL/min = 300 mg every third day <10 mL/min = 300 mg once weekly
(Note: no dose adjustment necessary for abacavir).
