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AIDS Research and Treatment
Volume 2011, Article ID 890308, 8 pages
http://dx.doi.org/10.1155/2011/890308
Research Article

Predictors of Weight Change in Male HIV-Positive Injection Drug Users Initiating Antiretroviral Therapy in Hanoi, Vietnam

1Department of Public Health and Community Medicine, Tufts University School of Medicine, Jaharis 265, Boston, MA 02111, USA
2Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
3Bach Mai Hospital, Center of Pathology, Hanoi, Vietnam
4National Hospital of Tropical Diseases, Hanoi, Vietnam

Received 16 January 2011; Revised 9 May 2011; Accepted 9 May 2011

Academic Editor: Glenda Gray

Copyright © 2011 Alice M. Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We examined clinical and nutritional predictors of weight change over two consecutive 6-month intervals among 99 HIV-positive male injection drug users initiating antiretroviral therapy (ART) in Hanoi, Vietnam. The average weight gain was 3.1 ± 4.8 kg in the first six months after ART and 0.8 ± 3.0 kg in the following six months. Predictors of weight change differed by interval. In the first interval, CD4 < 200 cells/μL, excellent/very good adherence to ART, bothersome nausea, and liquid supplement use were all associated with positive weight changes. Moderate to heavy alcohol use and tobacco smoking were associated with negative weight changes. In the second interval, having a CD4 count <200 cells/μL at the beginning of the interval and tobacco smoking were the only significant predictors and both were associated with negative weight changes. We identified several potential areas for interventions to promote weight gain immediately after starting ART in this population. Studies are needed to determine whether improving weight prior to, or at, ART initiation will result in improved outcomes on ART.