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AIDS Research and Treatment
Volume 2011 (2011), Article ID 903480, 7 pages
http://dx.doi.org/10.1155/2011/903480
Research Article

Patient Characteristics Associated with HCV Treatment Adherence, Treatment Completion, and Sustained Virologic Response in HIV Coinfected Patients

1Health Unit, RAND Corporation, 1776 Main Street, P.O. Box 2138, Santa Monica, CA 90407, USA
2Health Unit, RAND Corporation, Arlington, VA 22202, USA
3AIDS Healthcare Foundation, Los Angeles, CA 90028, USA
4Infectious Diseases Section, Greater Los Angeles Veterans Administration, Los Angeles, CA 90073, USA
5Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA 90509, USA

Received 31 May 2011; Revised 30 August 2011; Accepted 31 August 2011

Academic Editor: Nancy A. Hessol

Copyright © 2011 Glenn Wagner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Di Martino, P. Rufat, N. Boyer et al., “The influence of human immunodeficiency virus coinfection on chronic hepatitis C in injection drug users: a long-term retrospective cohort study,” Hepatology, vol. 34, no. 6, pp. 1193–1199, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Bica, B. McGovern, R. Dhar et al., “Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection,” Clinical Infectious Diseases, vol. 32, no. 3, pp. 492–497, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Cacoub, L. Geffray, E. Rosenthal, C. Perronne, P. Veyssier, and G. Raguin, “Mortality among human immunodeficiency virus-infected patients with cirrhosis or hepatocellular carcinoma due to hepatitis C virus in French departments of internal medicine/infectious diseases, in 1995 and 1997,” Clinical Infectious Diseases, vol. 32, no. 8, pp. 1207–1214, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Rauch, M. Egger, J. Reichen, and H. Furrer, “Chronic hepatitis C in HIV-infected patients: low eligibility and applicability of therapy with pegylated interferon-α plus ribavirin,” Journal of Acquired Immune Deficiency Syndromes, vol. 38, no. 2, pp. 238–240, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. C. A. Fleming, D. E. Craven, D. Thornton, S. Tumilty, and D. Nunes, “Hepatitis C virus and human immunodeficiency virus coinfection in an urban population: low eligibility for interferon treatment,” Clinical Infectious Diseases, vol. 36, no. 1, pp. 97–100, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. L. E. Taylor, T. Costello, E. Alt, G. Yates, and K. Tashima, “Psychiatric illness and illicit drugs as barriers to hepatitis C treatment among HIV/hepatitis C virus co-infected individuals,” AIDS, vol. 16, no. 12, pp. 1700–1701, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. S. L. Fultz, A. C. Justice, A. A. Butt, L. Rabeneck, S. Weissman, and M. Rodriguez-Barradas, “Testing, referral, and treatment patterns for hepatitis C virus coinfection in a cohort of veterans with human immunodeficiency virus infection,” Clinical Infectious Diseases, vol. 36, no. 8, pp. 1039–1046, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. F. J. Torriani, M. Rodriguez-Torres, J. K. Rockstroh et al., “Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients,” New England Journal of Medicine, vol. 351, no. 5, pp. 438–450, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. R. T. Chung, J. Andersen, P. Volberding et al., “Peginterferon alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons,” New England Journal of Medicine, vol. 351, no. 5, pp. 451–459, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Carrat, F. Bani-Sadr, S. Pol et al., “Pegylated interferon alfa-2b vs standard interferon alfa-2b, plus ribavirin, for chronic hepatitis C in HIV-infected patients: a randomized controlled trial,” Journal of the American Medical Association, vol. 292, no. 23, pp. 2839–2848, 2004. View at Publisher · View at Google Scholar
  11. M. Laguno, J. Murillas, J. L. Blanco et al., “Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for treatment of HIV/HCV co-infected patients,” AIDS, vol. 18, pp. 27–36, 2004. View at Google Scholar
  12. N. Bräu, M. Rodriguez-Torres, D. Prokupek et al., “Treatment of chronic hepatitis C in HIV/HCV-coinfection with interferon α-2b+ full-course vs. 16-Week delayed ribavirin,” Hepatology, vol. 39, no. 4, pp. 989–998, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. R. P. Myers, Y. Benhamou, M. Bochet, V. Thibaulit, D. Mehri, and T. Poynard, “Pegylated interferon alpha 2b and ribavirin in HIV/hepatitis C virus-co-infected non-responders and relapsers to IFN-based therapy,” AIDS, vol. 18, no. 1, pp. 75–79, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Torriani and F. Soriano, “Chronic hepatitis C in HIV-infected individuals,” AIDS Reviews, vol. 2, no. 3, pp. 168–177, 2000. View at Google Scholar · View at Scopus
  15. M. P. Manns and H. Wedemeyer, “Treatment of hepatitis C in HIV-infected patients: significant progress but not the final step,” Journal of the American Medical Association, vol. 292, no. 23, pp. 2909–2913, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. M. P. Manns, J. McHutchison, S. Gordon et al., “Peginterferon alfa-2b plus ribavirin compared with interferonalfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial,” The Lancet, vol. 358, no. 9286, pp. 958–965, 2001. View at Publisher · View at Google Scholar
  17. S. J. Hadziyannis, H. Cheinquet, T. Morgan et al., “Peginterferon alfa-2a (40kD) (PEGASYS) in combination with ribavirin (RBV): efficacy and safety results from a phase III, randomized, double-blind, multicentre study examining effect of duration of treatment and RBV dose,” Journal of Hepatology, vol. 36, p. 3, 2002. View at Google Scholar
  18. J. G. McHutchison, M. P. Manns, K. Patel et al., “Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C,” Gastroenterology, vol. 123, no. 4, pp. 1061–1069, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. M. L. Shiffman, A. M. Di Bisceglie, K. L. Lindsay et al., “Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatment,” Gastroenterology, vol. 126, no. 4, pp. 1015–1023, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. F. Jen, P. Glue, S. Gupta, D. Zambas, and G. Hajian, “Population pharmacokinetic and pharmacodynamic analysis of ribavirin in patients with chronic hepatitis C,” Therapeutic Drug Monitoring, vol. 22, no. 5, pp. 555–565, 2000. View at Publisher · View at Google Scholar · View at Scopus
  21. C. R. Fumaz, J. A. Muñoz-Moreno, A. L. Ballesteros et al., “Influence of the type of pegylated interferon on the onset of depressive and neuropsychiatric symptoms in HIV-HCV coinfected patients,” AIDS Care, vol. 19, no. 1, pp. 138–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. S. R. Smith, A. S. Wahed, S. S. Kelley, H. S. Conjeevaram, P. R. Robuck, and M. W. Fried, “Assessing the validity of self-reported medication adherence in hepatitis C treatment,” Annals of Pharmacotherapy, vol. 41, no. 7-8, pp. 1116–1123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Weiss, L. Bhatti, D. T. Dieterich et al., “Hepatitis C patients' self-reported adherence to treatment with pegylated interferon and ribavirin,” Alimentary Pharmacology and Therapeutics, vol. 28, no. 3, pp. 289–293, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. P. A. Volberding, A. M. Levine, D. Dieterich, D. Mildvan, R. Mitsuyasu, and M. Saag, “Anemia in HIV infection: clinical impact and evidence-based management strategies,” Clinical Infectious Diseases, vol. 38, no. 10, pp. 1454–1463, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. N. H. Afdhal, “Role of epoetin alfa in maintaining ribavirin dose,” Gastroenterology Clinics of North America, vol. 33, supplement 1, pp. S25–S35, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. M. W. Fried, M. Shiffman, R. Reddy et al., “Pegylated interferon alfa-2a in combination with ribavirin: efficacy and safety results from a phase 3 randomized, actively controlled multicenter study,” Gastroenterology, vol. 120, p. 55, 2001. View at Google Scholar
  27. J. M. Loftis and P. Hauser, “Comanagement of depression and HCV treatment,” Psychiatric Annals, vol. 33, no. 6, pp. 385–391, 2003. View at Google Scholar · View at Scopus
  28. M. A. Chesney, “Factors affecting adherence to antiretroviral therapy,” Clinical Infectious Diseases, vol. 30, supplement 2, pp. S171–S176, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. J. R. Ickovics, A. Cameron, R. Zackin et al., “Consequences and determinants of adherence to antiretroviral medication: results from Adult AIDS Clinical Trials Group protocol 370,” Antiviral Therapy, vol. 7, no. 3, pp. 185–193, 2002. View at Google Scholar · View at Scopus
  30. G. J. Wagner, “Predictors of antiretroviral adherence as measured by self-report, electronic monitoring, and medication diaries,” AIDS Patient Care and STDs, vol. 16, no. 12, pp. 599–608, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. G. J. Wagner, K. Chan Osilla, and J. Garnett, “Provider and patient correlates of provider decisions to recommend HCV treatment to HIV co-infected patients,” Journal of International Association of Physicians in AIDS Care. In press.
  32. K. Chan Osilla, G. J. Wagner, L. Bhatti et al., “Patient and provider characteristics associated with the decision of HIV co-infected patients to start Hepatitis C treatment,” AIDS Patient Care and STDs, vol. 25, pp. 533–538, 2011. View at Google Scholar
  33. J. G. Rabkin and M. Chesney, “Treatment adherence to HIV medications: the Achilles heel of the new therapeutics,” in Psychosocial and Public Health Impacts of New HIV Therapies, D. G. Ostrow and S. C. Kalichman, Eds., pp. 61–82, Plenum, New York, NY, USA, 1999. View at Google Scholar
  34. A. Fukuda, H. Kobayashi, K. Teramura, S. Yoshimoto, and N. Ohsawa, “Effects of interferon-α on peripheral neutrophil counts and serum granulocyte colony-stimulating factor levels in chronic hepatitis C patients,” Cytokines, Cellular and Molecular Therapy, vol. 6, no. 3, pp. 149–154, 2000. View at Google Scholar · View at Scopus
  35. M. Schaefer, F. Schmidt, C. Folwaczny et al., “Adherence and mental side effects during hepatitis C treatment with interferon alfa and ribavirin in psychiatric risk groups,” Hepatology, vol. 37, no. 2, pp. 443–451, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. B. R. Edlin, “Prevention and treatment of hepatitis C in injection drug users,” Hepatology, vol. 36, supplement 5, pp. S210–S219, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. J. M. Simoni, A. E. Kurth, C. R. Pearson, D. W. Pantalone, J. O. Merrill, and P. A. Frick, “Self-report measures of antiretroviral therapy adherence: a review with recommendations for HIV research and clinical management,” AIDS and Behavior, vol. 10, no. 3, pp. 227–245, 2006. View at Publisher · View at Google Scholar · View at Scopus