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AIDS Research and Treatment
Volume 2012, Article ID 103072, 5 pages
http://dx.doi.org/10.1155/2012/103072
Research Article

Assessing the Association between Leptin and Bone Mineral Density in HIV-Infected Men

1Department of Medicine, University of California, San Francisco, CA 94143, USA
2Division of Endocrinology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30 Room 3501K, San Francisco, CA 94110, USA
3Division of Hematology and Oncology, San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA
4Daiichi Sankyo Pharma Development, 399 Thornall Street N. 45, Edison, NJ 08837, USA
5Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California, Davis, 1093 Haring Hall, Davis, CA 95616, USA
6Department of Medicine, University General Hospital of Larissa, University of Thessaly, Mezourlo, TK 411-10 Larissa, Greece

Received 3 February 2012; Accepted 3 July 2012

Academic Editor: Glenda Gray

Copyright © 2012 Madhu N. Rao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. T. Brown and R. B. Qaqish, “Antiretroviral therapy and the prevalence of osteopenia and osteoporosis: a meta-analytic review,” AIDS, vol. 20, no. 17, pp. 2165–2174, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. G. A. McComsey, P. Tebas, E. Shane et al., “Bone disease in HIV infection: a practical review and recommendations for HIV care providers,” Clinical Infectious Diseases, vol. 51, no. 8, pp. 937–946, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Rosenthall and J. Falutz, “Bone mineral and soft-tissue changes in AIDS-associated lipoatrophy,” Journal of Bone and Mineral Metabolism, vol. 23, no. 1, pp. 53–57, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Aukrust, C. J. Haug, T. Ueland et al., “Decreased bone formative and enhanced resorptive markers in human immunodeficiency virus infection: indication of normalization of the bone- remodeling process during highly active antiretroviral therapy,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 1, pp. 145–150, 1999. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Karsenty, “Convergence between bone and energy homeostases: leptin regulation of bone mass,” Cell Metabolism, vol. 4, no. 5, pp. 341–348, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. T. Thomas, B. Burguera, L. J. Melton et al., “Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women,” Bone, vol. 29, no. 2, pp. 114–120, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. L. A. Weiss, E. Barrett-Connor, D. Von Mühlen, and P. Clark, “Leptin predicts BMD and bone resorption in older women but not older men: the Rancho Bernardo Study,” Journal of Bone and Mineral Research, vol. 21, no. 5, pp. 758–764, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Blain, A. Vuillemin, F. Guillemin et al., “Serum leptin level is a predictor of bone mineral density in postmenopausal women,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1030–1035, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Sato, N. Takeda, H. Sarui et al., “Association between serum leptin concentrations and bone mineral density, and biochemical markers of bone turnover in adult men,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 11, pp. 5273–5276, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Ducy, M. Amling, S. Takeda et al., “Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass,” Cell, vol. 100, no. 2, pp. 197–207, 2000. View at Google Scholar · View at Scopus
  11. C. T. Montague, J. B. Prins, L. Sanders, J. E. Digby, and S. O'Rahilly, “Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution,” Diabetes, vol. 46, no. 3, pp. 342–347, 1997. View at Google Scholar · View at Scopus
  12. T. R. Nagy, B. A. Gower, C. A. Trowbridge, C. Dezenberg, R. M. Shewchuk, and M. I. Goran, “Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children,” Journal of Clinical Endocrinology and Metabolism, vol. 82, no. 7, pp. 2148–2152, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Grinspoon and A. Carr, “Cardiovascular risk and body-fat abnormalities in HIV-infected adults,” New England Journal of Medicine, vol. 352, no. 1, pp. 48–62, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. J. E. Gallant, S. Staszewski, A. L. Pozniak et al., “Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial,” Journal of the American Medical Association, vol. 292, no. 2, pp. 191–201, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Mulligan, V. W. Tai, H. Algren et al., “Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapy,” Journal of Acquired Immune Deficiency Syndromes, vol. 26, no. 5, pp. 443–448, 2001. View at Google Scholar · View at Scopus
  16. G. K. Sakkas, K. Mulligan, M. Dasilva et al., “Creatine fails to augment the benefits from resistance training in patients with HIV infection: a randomized, double-blind, placebo-controlled study,” PLoS ONE, vol. 4, no. 2, Article ID e4605, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. D. I. Abrams, J. F. Hilton, R. J. Leiser et al., “Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, Placebo-controlled clinical trial,” Annals of Internal Medicine, vol. 139, no. 4, pp. 258–I44, 2003. View at Google Scholar · View at Scopus
  18. J. C. Lo, K. Mulligan, M. A. Noor et al., “The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulation,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 8, pp. 3480–3487, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. J. C. Lo, K. Mulligan, V. W. Tai, H. Algren, and M. Schambelan, “'Buffalo hump' in men with HIV-1 infection,” The Lancet, vol. 351, no. 9106, pp. 867–870, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Faraj, P. J. Havel, S. Phélis, D. Blank, A. D. Sniderman, and K. Cianflone, “Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1594–1602, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Martínez, M. Larrousse, D. Podzamczer, and J. M. Gatell, “Objective amount of limb fat in HIV-infected subjects with subjective diagnosis of lipoatrophy,” HIV Medicine, vol. 10, no. 4, pp. 257–261, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Madeddu, A. Spanu, F. Chessa et al., “Serum leptin and bone metabolism in HIV patients treated with highly active antiretroviral therapy,” Quarterly Journal of Nuclear Medicine and Molecular Imaging, vol. 53, no. 3, pp. 290–301, 2009. View at Google Scholar · View at Scopus