Research Article

Orthotopic Liver Transplantation in Human-Immunodeficiency-Virus-Positive Patients in Germany

Table 3

Causes of Death of HIV-infected German patients with a liver graft.

Patient No.Age (yrs)/genderCause of end-stage organ failureCDC stage/CD4 count before OLTInitial HAART after OLTStart of HAART (days after OLT)HCV or HBV therapyFollowup (Months)Causes of death

158/mHCVA3/168/ LD4T/ 3TC/ABC53IFN/RBV93Kidney failure

237/mHCV/HBV/HDVC3/86/ LAZT/3TC/ABC2IFN/RBV 3,5 months after OLT56Re-retransplantation for primary graft failure, progressive hepatitis, HCV-positive donor organ, sepsis

336/mHCVA3/219/ L3TC/D4T/EFV4No HCV therapy31Secondary graft failure for chemotherapy for Hodgkin’s disease and chronic HCV

441/mHCVA2/380/ LTVD/FPV/RTV75No HCV therapy25Progressive metastasis of HCC

552/mHCVB1LPV/EFV1No HCV therapy13Progressive sceletal metastasis of HCC, abscess after TACE

648/fHCVA1/621/ LAZT/3TC/NLF2No HCV therapy10Secondary graft failure for progressive cholestatic hepatitis

745/mHCVB2/372/ LABC/3TC/EFV34IFN/RBV therapy8Anastomic leak with massive bleeding, multiorgan failure, sepsis

857/mHBVA3/202/ LD4T/ 3TC/ABC55HBs-Ig/lamivudin3Intrathoracic hemorrhage after placement of a thoracic drain

949/mHBVB3/196/ LAZT/ 3TC29 HBs-Ig/lamivudin3Thrombosis of A. hepatica, graft failure due to organ rejection, biliary leakage and intra-abdominal abscess, sepsis, multiorgan failure

1045/mHCVC3/193/ LLPV/SQV1No HCV therapy3Pseudomonas sepsis, kidney failure after combined liver kidney transplantation

1157/mHCV—/622/ Lno datano dataNo HCV therapy2Retransplantation due to primary graft nonfunction and organ rejection, kidney failure

1248/mHCVB2/210/ Lno datano dataNo HCV therapy1Sepsis, multiorgan failure

1333/mBudd-Chiari-SyndromeB2/595/ Lnoneno datano data1Sepsis

3TC: lamivudine, ABC: abacavir, D4T: stavudine, EFV: efavirenz, AZT: azidothymidine, NLF: nelfinavir, LPV: lopinavir, SQV: saquinavir, TVD: truvada, FPV: fosamprenavir, RTV: ritonavir, TACE: transarterial chemoembolisation, NTX: kidney transplantation, IFN: interferon, RBV: ribavirin, HBs-Ig: HBs hyperimmunoglobulin, HCV: hepatitis C virus, HBV: hepatitis B virus, HDV: hepatitis D virus, m: male, f: female.