Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection
Table 1
(a) Demographic and immunovirological characteristics of study population. (b) Peripheral T lymphocyte immune phenotypes of study population.
(a)
Characteristics
Patients ()
Age, years*
37 (31–46)
Gender, male°
225 (82)
Risk group°
Homosexual
152 (55)
Heterosexual
111 (40)
IDUs
10 (4)
Other
2 (1)
Migrants°
73 (26)
HCV coinfection°
16 (6)
Calendar year of presentation°
2007
85 (31)
2008
61 (22)
2009
61 (22)
2010
61 (22)
January–March 2011
7 (3)
AIDS presenters°
49 (18)
HIV-RNA log10 cp/mL*
4.37 (2.78–5.16)
CD4+ T cells/L*
396 (234–555)
(b)
T-cells immunophenotypes
Patients ()
CD4 T cells %*
22 (14–30)
CD8 T cells %*
51 (42–60)
CD4+CD127+ cells %*
12 (7–20)
CD8+CD127+ cells %*
11 (8–17)
CD4+CD95+ cells %*
2 (1–4)
CD8+CD95+ cells %*
2 (1–4)
CD8+CD38+ cells %*
6 (3–12)
CD8+CD38+CD45R0+ cells %*
12 (7–20)
Data are presented as *median, (interquartile range, IQR) and °absolute number, (%). IDUs: injection drug users; migrants: people who were born outside the European community (including people from Eastern Europe, Africa, Asia, and Latin America); HCV: hepatitis C virus.
