Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection
Table 5
Multivariate logistic regression analysis of the association of demographic and HIV-related characteristic with advanced HIV disease at presentation.
Advanced HIV disease at presentation
P
(CD4 T cell 200 and/or AIDS-defining event)
AOR
95% CI
(a) Patient factors
Age, years
1.040
1.010–1.071
0.008
Risk group°
Heterosexual
1.788
0.901–3.546
0.096
Other
reference
(b) T-cells immune phenotypes
CD8+ T cells/L % (each unit more)
1.051
1.022–1.081
0.001
CD4+CD127+ cells/L % (each unit more)
0.909
0.878–0.942
0.0001
CD8+CD95+ cells/L % (each unit more)
1.063
0.841–1.200
0.327
CD8+CD38+ cells/L % (each unit more)
1.065
1.020–1.112
0.004
CD8+CD38+CD45R0+ cells/L % (each unit more)
0.955
0.916–0.996
0.032
AOR: adjusted odds ratio; 95% CI, 95% confidence interval. was considered to denote statistical significance. Other: homosexual, intravenous drug users, and other risks groups.
