Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F₁ Mice

Table 2

Plasma lactate levels in B6C3F₁ mice.

AZT dose (mg/kg/d)	Plasma lactate level (mg/dL)
	0-week		12-week
	Male	Female	Male	Female
0	101.4±10.3	126.5±15.4	71.5 ± 1.8^a	62.0 ± 3.2^a,b
400	100.0±3.7	92.6±9.2	79.3 ± 8.0^a	56.0 ± 5.8^a,b
500	96.7±3.2	87.5±2.2	57.9 ± 5.2^a	56.3 ± 4.2^a
600	92.6±4.2	91.2±2.6	65.7 ± 4.3^a	52.7 ± 2.3^a,b

^aindicates a significant (𝑃<0.05) difference in plasma lactate levels at 12-week compared to 0-week for each sex.
^bindicates a significant (𝑃<0.05) sex-related difference in plasma lactate levels in female mice compared to male counterparts at 12-week.
Values are presented as the mean ± SEM (𝑁=4).